RegulonDB RegulonDB 10.8: Gene Form
   

cysU gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cysA cysP cysW cysU ucpA CysB anti-terminator cysPp cysPp TSS_2741 TSS_2741 TSS_2740 TSS_2740 TSS_2739 TSS_2739

Gene      
Name: cysU    Texpresso search in the literature
Synonym(s): ECK2419, EG10197, b2424, cysT
Genome position(nucleotides): 2541679 <-- 2542512 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.24
External database links:  
ASAP:
 ABE-0007990
CGSC:
 17719
ECHOBASE:
 EB0194
OU-MICROARRAY:
 b2424
PortEco:
 cysU
STRING:
 511145.b2424
COLOMBOS: cysU


Product      
Name: sulfate/thiosulfate ABC transporter inner membrane subunit CysU
Synonym(s): CysT, CysU
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 30.292
Isoelectric point: 8.185
Motif(s):
 
Type Positions Sequence
64 -> 84 LLSAFVASIFNGVFGLLMAWI
215 -> 235 VIFIAGNIAWKTEVTSLMIFV
60 -> 263 YKVTLLSAFVASIFNGVFGLLMAWILTRYRFPGRTLLDALMDLPFALPTAVAGLTLASLFSVNGFYGEWLAKFDIKVTYTWLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFCKVVLPELSPALVAGVALSFTRSLGEFGAVIFIAGNIAWKTEVTSLMIFVRLQEFDYPAASAIASVILAASLLLLFSI
76 -> 274 VFGLLMAWILTRYRFPGRTLLDALMDLPFALPTAVAGLTLASLFSVNGFYGEWLAKFDIKVTYTWLGIAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFCKVVLPELSPALVAGVALSFTRSLGEFGAVIFIAGNIAWKTEVTSLMIFVRLQEFDYPAASAIASVILAASLLLLFSINTLQSRFGRRV
136 -> 156 VTYTWLGIAVAMAFTSIPFVV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.2 - sulfur metabolism
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
molecular_function GO:0015419 - ATPase-coupled sulfate transmembrane transporter activity
biological_process GO:0008272 - sulfate transport
GO:0055085 - transmembrane transport
GO:1902358 - sulfate transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 CYST-MONOMER
ECOLIWIKI:
 b2424
INTERPRO:
 IPR005667
INTERPRO:
 IPR035906
INTERPRO:
 IPR011865
INTERPRO:
 IPR000515
PANTHER:
 PTHR30406
PANTHER:
 PTHR30406:SF10
PFAM:
 PF00528
PRIDE:
 P16701
PRODB:
 PRO_000022388
PROSITE:
 PS50928
REFSEQ:
 NP_416919
SMR:
 P16701
UNIPROT:
 P16701


Operon      
Name: cysPUWAM         
Operon arrangement:
Transcription unit        Promoter
cysPUWAM


Transcriptional Regulation      
Display Regulation             
Activated by: CysB
Repressed by: H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2739 2540872 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2740 2540960 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2741 2541513 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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