RegulonDB RegulonDB 10.8: Gene Form
   

dacC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dacC deoR gstB yliI dacCp dacCp TSS_988 TSS_988 gstBp gstBp

Gene      
Name: dacC    Texpresso search in the literature
Synonym(s): ECK0829, EG10203, b0839
Genome position(nucleotides): 880727 --> 881929 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.7
External database links:  
ASAP:
 ABE-0002860
CGSC:
 34706
ECHOBASE:
 EB0199
OU-MICROARRAY:
 b0839
PortEco:
 dacC
STRING:
 511145.b0839
COLOMBOS: dacC


Product      
Name: D-alanyl-D-alanine carboxypeptidase DacC
Synonym(s): DacC, PBP6, PBP6a, murein DD-carboxypeptidase, penicillin-binding protein 6
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space,inner membrane
Molecular weight: 43.609
Isoelectric point: 8.375
Motif(s):
 
Type Positions Sequence
285 -> 376 FETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEE
30 -> 266 QTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTAGAGYNLVASATQGDMRLISVVLGAKT
132 -> 134 SGN
231 -> 231 V
235 -> 238 KTGT

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.7 - murein (peptidoglycan)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
molecular_function GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0004180 - carboxypeptidase activity
GO:0004175 - endopeptidase activity
GO:0009002 - serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0008658 - penicillin binding
GO:0042803 - protein homodimerization activity
biological_process GO:0006508 - proteolysis
GO:0009252 - peptidoglycan biosynthetic process
GO:0042493 - response to drug
GO:0008360 - regulation of cell shape
GO:0071555 - cell wall organization
External database links:  
ECOCYC:
 EG10203-MONOMER
ECOLIWIKI:
 b0839
INTERPRO:
 IPR018044
INTERPRO:
 IPR037167
INTERPRO:
 IPR015956
INTERPRO:
 IPR012907
INTERPRO:
 IPR012338
INTERPRO:
 IPR001967
MINT:
 P08506
MODBASE:
 P08506
PDB:
 3ITB
PDB:
 3IT9
PDB:
 3ITA
PFAM:
 PF00768
PFAM:
 PF07943
PRIDE:
 P08506
PRINTS:
 PR00725
PRODB:
 PRO_000022394
REFSEQ:
 NP_415360
SMART:
 SM00936
SMR:
 P08506
SWISSMODEL:
 P08506
UNIPROT:
 P08506


Operon      
Name: dacC         
Operon arrangement:
Transcription unit        Promoter
dacC


Transcriptional Regulation      
Display Regulation             
Activated by: BolA
Repressed by: BolA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_988 880618 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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