RegulonDB RegulonDB 10.6.3: Gene Form
   

deoC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yjjI deoA deoC yjjW DeoR ModE CRP CytR CytR CytR CRP Fis DeoR DeoR DeoR DeoR DeoR terminator TSS_5164 TSS_5164 TSS_5163 TSS_5163 deoCp2 deoCp2 TSS_5162 TSS_5162 deoCp1 deoCp1

Gene      
Name: deoC    Texpresso search in the literature
Synonym(s): ECK4373, EG10221, b4381, dra, thyR, tlr
Genome position(nucleotides): 4617323 --> 4618102 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.38
External database links:  
ASAP:
ABE-0014371
CGSC:
866
ECHOBASE:
EB0217
ECOCYC:
EG10221
ECOLIHUB:
deoC
OU-MICROARRAY:
b4381
REGULONDB:
b4381
STRING:
511145.b4381
M3D: deoC
COLOMBOS: deoC
PortEco: b4381


Product      
Name: deoxyribose-phosphate aldolase
Synonym(s): DeoC, Dra, ThyR, Tlr
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 27.734
Isoelectric point: 5.423
Motif(s):
 
Type Positions Sequence
259 -> 259 Y
18 -> 18 T
137 -> 137 K
47 -> 47 C
102 -> 102 D

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.33 - nucleotide and nucleoside conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016829 - lyase activity
GO:0004139 - deoxyribose-phosphate aldolase activity
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0015949 - nucleobase-containing small molecule interconversion
GO:0016052 - carbohydrate catabolic process
GO:0009264 - deoxyribonucleotide catabolic process
GO:0046386 - deoxyribose phosphate catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Alikhanian SI., et al., 1966
[2] Breitman TR., et al., 1967
[3] Buxton RS. 1975
[4] Lomax MS., et al., 1968
External database links:  
ECOCYC:
DEOXYRIBOSE-P-ALD-MONOMER
ECOLIWIKI:
b4381
INTERPRO:
IPR023649
INTERPRO:
IPR013785
INTERPRO:
IPR011343
INTERPRO:
IPR002915
MODBASE:
P0A6L0
PANTHER:
PTHR10889
PDB:
1JCJ
PDB:
5EMU
PDB:
5EL1
PDB:
5EKY
PDB:
1P1X
PDB:
1KTN
PDB:
1JCL
PFAM:
PF01791
PRIDE:
P0A6L0
PRODB:
PRO_000022429
PROTEINMODELPORTAL:
P0A6L0
REFSEQ:
NP_418798
SMART:
SM01133
SMR:
P0A6L0
UNIPROT:
P0A6L0


Operon      
Name: deoCABD         
Operon arrangement:
Transcription unit        Promoter
deoCABD
deoCABD
deoBD
deoA


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, Fis
Repressed by: CRP, DeoR, ModE, CytR


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_5162 4617277 forward nd [RS-EPT-CBR] [5]
  promoter TSS_5163 4617293 forward nd [RS-EPT-CBR] [5]
  promoter TSS_5164 4617361 forward nd [RS-EPT-CBR] [5]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Alikhanian SI., Iljina TS., Kaliaeva ES., Kameneva SV., Sukhodolec VV., 1966, A genetical study of thymineless mutants of E. coli K12., Genet Res 8(1):83-100

 [2] Breitman TR., Bradford RM., 1967, The absence of deoxyriboaldolase activity in a thymineless mutant of Escherichia coli strain 15: a possible explanation for the low thymine requirement of some thymineless strains., Biochim Biophys Acta 138(1):217-20

 [3] Buxton RS., 1975, Genetic analysis of thymidine-resistant and low-thymine-requiring mutants of Escherichia coli K-12 induced by bacteriophage Mu-1., J Bacteriol 121(2):475-84

 [4] Lomax MS., Greenberg GR., 1968, Characteristics of the deo operon: role in thymine utilization and sensitivity to deoxyribonucleosides., J Bacteriol 96(2):501-14

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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