RegulonDB RegulonDB 10.7: Gene Form
   

dicB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ydfE ydfD dicB insD-7 dicF terminator anti-terminator anti-anti-terminator dicBp dicBp

Gene      
Name: dicB    Texpresso search in the literature
Synonym(s): ECK1569, EG10227, b1575, ftsT
Genome position(nucleotides): 1649609 --> 1649797 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
35.98
External database links:  
ASAP:
ABE-0005260
CGSC:
18424
ECHOBASE:
EB0223
OU-MICROARRAY:
b1575
PORTECO:
dicB
REGULONDB:
b1575
STRING:
511145.b1575
M3D: dicB
COLOMBOS: dicB
PortEco: b1575


Product      
Name: Qin prophage; cell division inhibition protein DicB
Synonym(s): DicB, FtsT
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 6.964
Isoelectric point: 8.96
Motif(s):
 
Type Positions Sequence
1 -> 62 MKTLLPNVNTSEGCFEIGVTISNPVFTEDAINKRKQERELLNKICIVSMLARLRLMPKGCAQ
39 -> 39 E

 

Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.2 - cell cycle physiology
  8 - extrachromosomal --> 8.1 - prophage genes and phage related functions
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
biological_process GO:0051301 - cell division
GO:0007049 - cell cycle
GO:0051302 - regulation of cell division
GO:0051782 - negative regulation of cell division
Note(s): Note(s): ...[more].
Evidence: [IE] Inferred from experiment
[IGI] Inferred from genetic interaction
[IMP] Inferred from mutant phenotype
Reference(s): [1] Barcellini-Couget S., et al., 1988
[2] Bejar S., et al., 1988
[3] Bejar S., et al., 1985
[4] Cam K., et al., 1995
[5] Johnson JE., et al., 2002
[6] Labie C., et al., 1990
[7] Yun SH., et al., 2012
[8] Zhou H., et al., 2005
[9] de Boer PA., et al., 1990
External database links:  
DIP:
DIP-9440N
ECOCYC:
EG10227-MONOMER
ECOLIWIKI:
b1575
INTERPRO:
IPR008022
PFAM:
PF05358
PRIDE:
P09557
PRODB:
PRO_000022444
PRODOM:
PD053043
PROTEINMODELPORTAL:
P09557
REFSEQ:
NP_416092
UNIPROT:
P09557


Operon      
Name: dicB-ydfDE-insD-7-intQ         
Operon arrangement:
Transcription unit        Promoter
dicB-ydfDE-insD-intQ


Transcriptional Regulation      
Display Regulation             
Repressed by: DicA


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1869 1651862 reverse nd [RS-EPT-CBR] [10]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Barcellini-Couget S., Galucci P., Bouche JP., 1988, Escherichia coli dicB operon includes a truncated IS2 element., Nucleic Acids Res 16(21):10388

 [2] Bejar S., Bouche F., Bouche JP., 1988, Cell division inhibition gene dicB is regulated by a locus similar to lambdoid bacteriophage immunity loci., Mol Gen Genet 212(1):11-9

 [3] Bejar S., Bouche JP., 1985, A new dispensable genetic locus of the terminus region involved in control of cell division in Escherichia coli., Mol Gen Genet 201(2):146-50

 [4] Cam K., Cuzange A., Bouche JP., 1995, Sigma S-dependent overexpression of ftsZ in an Escherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA., Mol Gen Genet 248(2):190-4

 [5] Johnson JE., Lackner LL., de Boer PA., 2002, Targeting of (D)MinC/MinD and (D)MinC/DicB complexes to septal rings in Escherichia coli suggests a multistep mechanism for MinC-mediated destruction of nascent FtsZ rings., J Bacteriol 184(11):2951-62

 [6] Labie C., Bouche F., Bouche JP., 1990, Minicell-forming mutants of Escherichia coli: suppression of both DicB- and MinD-dependent division inhibition by inactivation of the minC gene product., J Bacteriol 172(10):5852-5

 [7] Yun SH., Ji SC., Jeon HJ., Wang X., Kim SW., Bak G., Lee Y., Lim HM., 2012, The CnuK9E H-NS complex antagonizes DNA binding of DicA and leads to temperature-dependent filamentous growth in E. coli., PLoS One 7(9):e45236

 [8] Zhou H., Lutkenhaus J., 2005, MinC mutants deficient in MinD- and DicB-mediated cell division inhibition due to loss of interaction with MinD, DicB, or a septal component., J Bacteriol 187(8):2846-57

 [9] de Boer PA., Crossley RE., Rothfield LI., 1990, Central role for the Escherichia coli minC gene product in two different cell division-inhibition systems., Proc Natl Acad Sci U S A 87(3):1129-33

 [10] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


RegulonDB