Gene
Name:	frdC
Synonym(s):	ECK4148, EG10332, b4152
Genome position(nucleotides):	4379377 <-- 4379772 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	49.24
External database links:

ASAP:	ABE-0013598
CGSC:	740
ECHOBASE:	EB0328
ECOLIHUB:	frdC
OU-MICROARRAY:	b4152
STRING:	511145.b4152
COLOMBOS:	frdC

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_4968	4379152	reverse	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4969	4379156	reverse	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4970 (cluster)	4379163	reverse	For this promoter, there is a cluster of 2 transcription start sites,in the interval 4379162 to 4379163, where the highest frequency is at position 4377185. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[3]
promoter	frdDp2	4379433	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: -1.01. P-value: 4.373e-6 Read more >	[ICWHO]	[4]
promoter	TSS_4971	4379467	reverse	nd	[RS-EPT-CBR]	[3]
promoter	frdDp1	4379473	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: -1.49. P-value: 1.738e-5 Read more >	[ICWHO]	[4]
promoter	frdDp7	4379474	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.28. P-value: 3.167e-5 Read more >	[ICWHO]	[4]
promoter	TSS_4972	4379642	reverse	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4973	4380402	reverse	nd	[RS-EPT-CBR]	[3]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Kashyap DR., Kuzma M., Kowalczyk DA., Gupta D., Dziarski R., 2017, Bactericidal peptidoglycan recognition protein induces oxidative stress in Escherichia coli through a block in respiratory chain and increase in central carbon catabolism., Mol Microbiol 105(5):755-776
[2] Westenberg DJ., Gunsalus RP., Ackrell BA., Sices H., Cecchini G., 1993, Escherichia coli fumarate reductase frdC and frdD mutants. Identification of amino acid residues involved in catalytic activity with quinones., J Biol Chem 268(2):815-22
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Transcriptional Regulation
	Display Regulation
Activated by:	FNR, DcuR
Repressed by:	NarL