RegulonDB RegulonDB 11.1: Gene Form
   

frdC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

frdB frdC frdD frdA anti-anti-terminator anti-terminator TSS_4973 TSS_4973 TSS_4972 TSS_4972 frdDp7 frdDp7 frdDp1 frdDp1 TSS_4971 TSS_4971 frdDp2 frdDp2 TSS_4970 (cluster) TSS_4970 (cluster) TSS_4969 TSS_4969 TSS_4968 TSS_4968

Gene      
Name: frdC    Texpresso search in the literature
Synonym(s): ECK4148, EG10332, b4152
Genome position(nucleotides): 4379377 <-- 4379772
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 49.24
External database links:  
ASAP:
 ABE-0013598
CGSC:
 740
ECHOBASE:
 EB0328
ECOLIHUB:
 frdC
OU-MICROARRAY:
 b4152
STRING:
 511145.b4152
COLOMBOS: frdC


Product      
Name: fumarate reductase membrane protein FrdC
Synonym(s): FrdC
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 15.015
Isoelectric point: 10.321
Motif(s):
 
Type Positions Sequence Comment
3 -> 128 TKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGFVDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVATIVILFVA
22 -> 49 FYRFYMLREGTAVPAVWFSIELIFGLFA UniProt: Helical;
29 -> 30 RE UniProt: Menaquinone binding; Sequence Annotation Type: region of interest.
66 -> 90 NPVIVIINLITLAAALLHTKTWFEL UniProt: Helical;
105 -> 128 GPEPIIKSLWAVTVVATIVILFVA UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.5 - fermentation
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.2 - electron acceptors
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
GO:0045284 - plasma membrane fumarate reductase complex
molecular_function GO:0102040 - fumarate reductase (menaquinone)
GO:0000104 - succinate dehydrogenase activity
biological_process GO:0006113 - fermentation
GO:0009061 - anaerobic respiration
GO:0001539 - cilium or flagellum-dependent cell motility
GO:0044780 - bacterial-type flagellum assembly
Note(s): Note(s): ...[more].
Reference(s): [1] Kashyap DR., et al., 2017
[2] Westenberg DJ., et al., 1993
External database links:  
ALPHAFOLD:
 P0A8Q0
DIP:
 DIP-48082N
ECOCYC:
 FUM-MEMB1
ECOLIWIKI:
 b4152
INTERPRO:
 IPR003510
INTERPRO:
 IPR034804
MODBASE:
 P0A8Q0
PDB:
 3P4S
PDB:
 5VPN
PDB:
 3P4R
PDB:
 3P4Q
PDB:
 3P4P
PDB:
 3CIR
PDB:
 2B76
PDB:
 1L0V
PDB:
 1KF6
PDB:
 1KFY
PFAM:
 PF02300
PRIDE:
 P0A8Q0
PRODB:
 PRO_000022688
REFSEQ:
 NP_418576
SMR:
 P0A8Q0
UNIPROT:
 P0A8Q0


Operon      
Name: frdABCD         
Operon arrangement:
Transcription unit        Promoter
frdABCD
frdABCD


Transcriptional Regulation      
Display Regulation             
Activated by: FNR, DcuR
Repressed by: NarL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4968 4379152 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4969 4379156 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4970 (cluster) 4379163 reverse nd [RS-EPT-CBR] [3]
  promoter frdDp2 4379433 reverse nd [COMP-AINF] [4]
  promoter TSS_4971 4379467 reverse nd [RS-EPT-CBR] [3]
  promoter frdDp1 4379473 reverse nd [COMP-AINF] [4]
  promoter frdDp7 4379474 reverse nd [COMP-AINF] [4]
  promoter TSS_4972 4379642 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4973 4380402 reverse nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Kashyap DR., Kuzma M., Kowalczyk DA., Gupta D., Dziarski R., 2017, Bactericidal peptidoglycan recognition protein induces oxidative stress in Escherichia coli through a block in respiratory chain and increase in central carbon catabolism., Mol Microbiol 105(5):755-776

 [2] Westenberg DJ., Gunsalus RP., Ackrell BA., Sices H., Cecchini G., 1993, Escherichia coli fumarate reductase frdC and frdD mutants. Identification of amino acid residues involved in catalytic activity with quinones., J Biol Chem 268(2):815-22

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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