RegulonDB RegulonDB 11.1: Gene Form
   

fucP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

fucI fucP fucA CRP CRP Spot 42 Spot 42 terminator anti-terminator anti-anti-terminator anti-anti-terminator anti-terminator terminator fucPp fucPp fucAp fucAp fucOp fucOp

Gene      
Name: fucP    Texpresso search in the literature
Synonym(s): ECK2796, EG10352, b2801
Genome position(nucleotides): 2934235 --> 2935551
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 47.68
External database links:  
ASAP:
 ABE-0009187
CGSC:
 10875
ECHOBASE:
 EB0348
ECOLIHUB:
 fucP
OU-MICROARRAY:
 b2801
STRING:
 511145.b2801
COLOMBOS: fucP


Product      
Name: L-fucose:H+ symporter
Synonym(s): FucP, FucP fucose MFS transporter
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 47.545
Isoelectric point: 8.829
Motif(s):
 
Type Positions Sequence Comment
2 -> 438 GNTSIQTQSYRAVDKDAGQSRSYIIPFALLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGNIPTAELIPALCFAVIFIFARFRSQTATN UniProt: L-fucose-proton symporter.
27 -> 53 PFALLCSLFFLWAVANNLNDILLPQFQ UniProt: Helical.
33 -> 387 SLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFWPAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSNVPHQSQDVLDKMSPEQLSAYKHSLVLSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSASLSRLARIRHWRWAVLAQFCYVGAQTACWSYLIRYAVEEIPGMTAGFAANYLTGTMVCFFIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFAGGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFI
38 -> 38 W UniProt: Strong decrease in L-fucose transport..
46 -> 46 D UniProt: Loss of L-fucose transport..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0009679 - hexose:proton symporter activity
GO:0015150 - fucose transmembrane transporter activity
GO:0015517 - galactose:proton symporter activity
GO:0015518 - arabinose:proton symporter activity
GO:0015535 - fucose:proton symporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0008643 - carbohydrate transport
GO:0006004 - fucose metabolic process
GO:0015751 - arabinose transmembrane transport
GO:0015755 - fructose transmembrane transport
GO:0015756 - fucose transmembrane transport
GO:0015757 - galactose transmembrane transport
GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Bartkus JM., et al., 1986
[2] Elsinghorst EA., et al., 1994
[3] Zhu Y., et al., 1988
External database links:  
ALPHAFOLD:
 P11551
ECOCYC:
 FUCP-MONOMER
ECOLIWIKI:
 b2801
INTERPRO:
 IPR020846
INTERPRO:
 IPR036259
INTERPRO:
 IPR011701
INTERPRO:
 IPR005275
MODBASE:
 P11551
PDB:
 3O7Q
PDB:
 3O7P
PFAM:
 PF07690
PRIDE:
 P11551
PRODB:
 PRO_000022731
PROSITE:
 PS50850
REFSEQ:
 NP_417281
SMR:
 P11551
UNIPROT:
 P11551


Operon      
Name: fucPIKUR         
Operon arrangement:
Transcription unit        Promoter
fucPIKUR
fucU
fucR


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, FucR


RNA cis-regulatory element    
Attenuation: Transcriptional


Regulation by small RNA    
  Display Regulation
small RNA spf


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Bartkus JM., Mortlock RP., 1986, Isolation of a mutation resulting in constitutive synthesis of L-fucose catabolic enzymes., J Bacteriol 165(3):710-4

 [2] Elsinghorst EA., Mortlock RP., 1994, Molecular cloning of the Escherichia coli B L-fucose-D-arabinose gene cluster., J Bacteriol 176(23):7223-32

 [3] Zhu Y., Lin EC., 1988, A mutant crp allele that differentially activates the operons of the fuc regulon in Escherichia coli., J Bacteriol 170(5):2352-8

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