RegulonDB RegulonDB 8.7: Gene Form
   

glpA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

glpA glpT glpB glpC GlpR Fis FNR GlpR CRP Fis GlpR FNR CRP GlpR Fis Fis GlpR CRP Fis IHF Fis IHF GlpR GlpR GlpR anti-terminator anti-anti-terminator terminator yfaDp5 yfaDp5 glpABCp glpABCp glpTQp glpTQp

Gene      
Name: glpA    Texpresso search in the literature
Synonym(s): b2241
Genome position(nucleotides): 2350669 --> 2352297 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
57.34
External database links:  
ECOCYC:
EG10391
GENBANK:
1788574
GENBANK_RefSeq:
16130176
OU-MICROARRAY:
b2241
M3D: glpA
COLOMBOS: glpA
PortEco: b2241


Product      
Name: anaerobic glycerol-3-phosphate dehydrogenase subunit A
Synonym(s): GlpA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,inner membrane
Molecular weight: 58.958
Isoelectric point: 6.62
Motif(s):
 
Type Positions Sequence
10 -> 38 DVIIIGGGATGAGIARDCALRGLRVILVE
329 -> 329 V

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.1 - electron donors
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.6 - misc. glycerol metabolism
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0009331 - glycerol-3-phosphate dehydrogenase complex
molecular_function GO:0005515 - protein binding
GO:0016491 - oxidoreductase activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0004368 - glycerol-3-phosphate dehydrogenase activity
GO:0010181 - FMN binding
GO:0052591 - sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity
biological_process GO:0009061 - anaerobic respiration
GO:0046174 - polyol catabolic process
GO:0006072 - glycerol-3-phosphate metabolic process
GO:0019563 - glycerol catabolic process
GO:0046168 - glycerol-3-phosphate catabolic process
GO:0055114 - oxidation-reduction process
Note(s): Note(s): ...[more].
Reference(s): [1] Ehrmann M., et al., 1987
[2] Freedberg WB., et al., 1973
[3] Iuchi S., et al., 1990
[4] Miki K., et al., 1979
[5] Schryvers A., et al., 1982
External database links:  
ECOCYC:
ANGLYC3PDEHYDROGSUBUNITA-MONOMER
EXPASY:
EC-1.1.5.3
GENPROTEC:
b2241


Operon      
Name: glpABC         
Operon arrangement:
Transcription unit        Promoter
glpABC


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yfaDp5 2354712 forward Similarity to the consensus
Read more >
[ICWHO] [6]


Evidence    

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Ehrmann M., Boos W., Ormseth E., Schweizer H., Larson TJ., 1987, Divergent transcription of the sn-glycerol-3-phosphate active transport (glpT) and anaerobic sn-glycerol-3-phosphate dehydrogenase (glpA glpC glpB) genes of Escherichia coli K-12., J Bacteriol. 169(2):526-32

 [2] Freedberg WB., Lin EC., 1973, Three kinds of controls affecting the expression of the glp regulon in Escherichia coli., J Bacteriol. 115(3):816-23

 [3] Iuchi S., Cole ST., Lin EC., 1990, Multiple regulatory elements for the glpA operon encoding anaerobic glycerol-3-phosphate dehydrogenase and the glpD operon encoding aerobic glycerol-3-phosphate dehydrogenase in Escherichia coli: further characterization of respiratory control., J Bacteriol. 172(1):179-84

 [4] Miki K., Silhavy TJ., Andrews KJ., 1979, Resolution of glpA and glpT loci into separate operons in Escherichia coli K-12 strains., J Bacteriol. 138(1):268-9

 [5] Schryvers A., Weiner JH., 1982, The anaerobic sn-glycerol-3-phosphate dehydrogenase: cloning and expression of the glpA gene of Escherichia coli and identification of the glpA products., Can J Biochem. 60(3):224-31

 [6] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol. 333(2):261-78


RegulonDB