RegulonDB RegulonDB 10.8: Gene Form
   

gltS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

recG xanP gltS xanPp4 xanPp4 xanPp5 xanPp5 TSS_4244 TSS_4244 gltSp3 gltSp3 TSS_4243 TSS_4243 TSS_4242 TSS_4242

Gene      
Name: gltS    Texpresso search in the literature
Synonym(s): ECK3643, EG10406, b3653, gltC
Genome position(nucleotides): 3827460 <-- 3828665 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.65
External database links:  
ASAP:
ABE-0011941
CGSC:
681
ECHOBASE:
EB0401
OU-MICROARRAY:
b3653
PortEco:
gltS
STRING:
511145.b3653
COLOMBOS: gltS


Product      
Name: glutamate:sodium symporter
Synonym(s): GltC, GltS
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 42.425
Isoelectric point: 8.609
Motif(s):
 
Type Positions Sequence
2 -> 366 FHLDTLATLVAATLTLLLGRKLVHSVSFLKKYTIPEPVAGGLLVALALLVLKKSMGWEVNFDMSLRDPLMLAFFATIGLNANIASLRAGGRVVGIFLIVVVGLLVMQNAIGIGMASLLGLDPLMGLLAGSITLSGGHGTGAAWSKLFIERYGFTNATEVAMACATFGLVLGGLIGGPVARYLVKHSTTPNGIPDDQEVPTAFEKPDVGRMITSLVLIETIALIAICLTVGKIVAQLLAGTAFELPTFVCVLFVGVILSNGLSIMGFYRVFERAVSVLGNVSLSLFLAMALMGLKLWELASLALPMLAILVVQTIFMALYAIFVTWRMMGKNYDAAVLAAGHCGFGLGATPTAIANMQAITERFGP
94 -> 115 VGIFLIVVVGLLVMQNAIGIGM
120 -> 137 GLDPLMGLLAGSITLSGG
213 -> 235 TSLVLIETIALIAICLTVGKIVA
243 -> 260 FELPTFVCVLFVGVILSN

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.1 - glutamate
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.5 - aspartate
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0015501 - glutamate:sodium symporter activity
biological_process GO:0006811 - ion transport
GO:0006865 - amino acid transport
GO:0015813 - L-glutamate transmembrane transport
GO:0006814 - sodium ion transport
GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-48023N
ECOCYC:
GLTS-MONOMER
ECOLIWIKI:
b3653
INTERPRO:
IPR004445
PANTHER:
PTHR36178
PFAM:
PF03616
PRIDE:
P0AER8
PRODB:
PRO_000022812
REFSEQ:
NP_418110
SMR:
P0AER8
UNIPROT:
P0AER8


Operon      
Name: gltS         
Operon arrangement:
Transcription unit        Promoter
gltS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4242 3826330 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4243 3826678 forward nd [RS-EPT-CBR] [1]
  promoter gltSp3 3828691 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_4244 3828765 reverse nd [RS-EPT-CBR] [1]
  promoter xanPp5 3828821 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter xanPp4 3828919 forward Similarity to the consensus
Read more >
[ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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