RegulonDB RegulonDB 10.7: Gene Form
   

hemA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hemA prfA lolB FNR TSS_1546 TSS_1546 TSS_1545 TSS_1545 TSS_1544 (cluster) TSS_1544 (cluster) TSS_1543 (cluster) TSS_1543 (cluster) hemAp1 hemAp1 TSS_1542 TSS_1542 hemAp2 hemAp2 lolBp lolBp TSS_1541 (cluster) TSS_1541 (cluster)

Gene      
Name: hemA    Texpresso search in the literature
Synonym(s): ECK1198, EG10427, b1210, gtrA
Genome position(nucleotides): 1263714 --> 1264970 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.34
Reference(s): [1] Verkamp E., et al., 1989
External database links:  
ASAP:
 ABE-0004064
CGSC:
 648
ECHOBASE:
 EB0422
OU-MICROARRAY:
 b1210
PORTECO:
 hemA
REGULONDB:
 b1210
STRING:
 511145.b1210
M3D: hemA
COLOMBOS: hemA
PortEco: b1210


Product      
Name: glutamyl-tRNA reductase
Synonym(s): GtrA, HemA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 46.307
Isoelectric point: 5.359
Motif(s):
 
Type Positions Sequence
50 -> 50 C
52 -> 52 R
114 -> 114 E
145 -> 145 S
170 -> 170 C

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.12 - heme, porphyrine
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016491 - oxidoreductase activity
GO:0008883 - glutamyl-tRNA reductase activity
GO:0042802 - identical protein binding
GO:0050661 - NADP binding
biological_process GO:0006779 - porphyrin-containing compound biosynthetic process
GO:0033014 - tetrapyrrole biosynthetic process
GO:0055114 - oxidation-reduction process
GO:0019353 - protoporphyrinogen IX biosynthetic process from glutamate
GO:0006782 - protoporphyrinogen IX biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
DIP:
 DIP-9877N
ECOCYC:
 GLUTRNAREDUCT-MONOMER
ECOLIWIKI:
 b1210
INTERPRO:
 IPR015896
INTERPRO:
 IPR018214
INTERPRO:
 IPR036291
INTERPRO:
 IPR036343
INTERPRO:
 IPR036453
INTERPRO:
 IPR006151
INTERPRO:
 IPR000343
INTERPRO:
 IPR015895
MODBASE:
 P0A6X1
PFAM:
 PF00745
PFAM:
 PF05201
PFAM:
 PF01488
PRIDE:
 P0A6X1
PRODB:
 PRO_000022874
PROSITE:
 PS00747
PROTEINMODELPORTAL:
 P0A6X1
REFSEQ:
 NP_415728
SMR:
 P0A6X1
UNIPROT:
 P0A6X1


Operon      
Name: hemA-prfA-prmC         
Operon arrangement:
Transcription unit        Promoter
hemA
hemA-prfA-prmC


Transcriptional Regulation      
Display Regulation             
Activated by: IHF, ArcA
Repressed by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1541 (cluster) 1263536 reverse For this promoter, there
Read more > 		[RS-EPT-CBR] [2]
  promoter TSS_1542 1263675 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1543 (cluster) 1264894 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [2]
  promoter TSS_1544 (cluster) 1264899 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [2]
  promoter TSS_1545 1265281 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1546 1265487 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Verkamp E., Chelm BK., 1989, Isolation, nucleotide sequence, and preliminary characterization of the Escherichia coli K-12 hemA gene., J Bacteriol 171(9):4728-35

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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