RegulonDB RegulonDB 10.8: Gene Form
   

degP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dgt degP cdaR CpxR CpxR CpxR cdaRp cdaRp TSS_305 TSS_305 degPp degPp TSS_304 TSS_304 TSS_303 (cluster) TSS_303 (cluster)

Gene      
Name: degP    Texpresso search in the literature
Synonym(s): ECK0160, EG10463, b0161, htrA, ptd
Genome position(nucleotides): 180884 --> 182308 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.96
External database links:  
ASAP:
ABE-0000551
CGSC:
30554
ECHOBASE:
EB0458
MIM:
610149
MIM:
616779
MIM:
600142
OU-MICROARRAY:
b0161
PortEco:
degP
STRING:
511145.b0161
COLOMBOS: degP


Product      
Name: periplasmic serine endoprotease DegP
Synonym(s): DegP, HtrA, Ptd, protease Do
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 49.354
Isoelectric point: 8.99
Motif(s):
 
Type Positions Sequence
195 -> 201 NPFGLGE
255 -> 255 L
467 -> 474 STIYLLMQ
207 -> 207 I
234 -> 236 GNS

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
  5 - cell processes --> 5.5 - adaptations --> 5.5.2 - temperature extremes
  5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
molecular_function GO:0005515 - protein binding
GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0004252 - serine-type endopeptidase activity
GO:0008236 - serine-type peptidase activity
GO:0042802 - identical protein binding
biological_process GO:0006457 - protein folding
GO:0006508 - proteolysis
GO:0006515 - protein quality control for misfolded or incompletely synthesized proteins
GO:0006979 - response to oxidative stress
GO:0009266 - response to temperature stimulus
GO:0009408 - response to heat
GO:0061077 - chaperone-mediated protein folding
External database links:  
DIP:
DIP-46256N
ECOCYC:
EG10463-MONOMER
ECOLIWIKI:
b0161
ECOO157CYC:
HTRA-MONOMER
INTERPRO:
IPR001940
INTERPRO:
IPR001478
INTERPRO:
IPR011782
INTERPRO:
IPR036034
INTERPRO:
IPR009003
MINT:
P0C0V0
MODBASE:
P0C0V0
PDB:
4A8D
PDB:
3OU0
PDB:
3MH7
PDB:
3MH6
PDB:
3MH5
PDB:
3MH4
PDB:
3CS0
PDB:
2ZLE
PDB:
1KY9
PDB:
3OTP
PFAM:
PF00595
PRIDE:
P0C0V0
PRINTS:
PR00834
PRODB:
PRO_000022425
PROSITE:
PS50106
REFSEQ:
NP_414703
SMART:
SM00228
SMR:
P0C0V0
SWISSMODEL:
P0C0V0
UNIPROT:
P0C0V0


Operon      
Name: degP         
Operon arrangement:
Transcription unit        Promoter
degP


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR
Repressed by: H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_303 (cluster) 180836 forward For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_304 180844 forward nd [RS-EPT-CBR] [1]
  promoter TSS_305 180846 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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