RegulonDB RegulonDB 10.8: Gene Form
   

hyaB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hyaB hyaA hyaC serT hyaD NarP NarL ArcA NarP NarL Fis IscR IscR YdeO ArcA Fis anti-anti-terminator anti-terminator hyaAp hyaAp serTp serTp

Gene      
Name: hyaB    Texpresso search in the literature
Synonym(s): ECK0964, EG10469, b0973
Genome position(nucleotides): 1033254 --> 1035047 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
56.52
External database links:  
ASAP:
ABE-0003288
CGSC:
31784
ECHOBASE:
EB0464
OU-MICROARRAY:
b0973
PortEco:
hyaB
STRING:
511145.b0973
COLOMBOS: hyaB


Shine dalgarno      
Sequence: gccaggcaatGAGGATaaacaggcATG


Product      
Name: hydrogenase 1 large subunit
Synonym(s): HyaB, hydrogenase 1 alpha; subunit
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space,inner membrane
Molecular weight: 66.253
Isoelectric point: 5.842
Motif(s):
 
Type Positions Sequence
52 -> 52 M
582 -> 582 H
583 -> 583 V
54 -> 582 RGLEIILQGRDPRDAWAFVERICGVCTGVHALASVYAIEDAIGIKVPDNANIIRNIMLATLWCHDHLVHFYQLAGMDWIDVLDALKADPRKTSELAQSLSSWPKSSPGYFFDVQNRLKKFVEGGQLGIFRNGYWGHPQYKLPPEANLMGFAHYLEALDFQREIVKIHAVFGGKNPHPNWIVGGMPCAINIDESGAVGAVNMERLNLVQSIITRTADFINNVMIPDALAIGQFNKPWSEIGTGLSDKCVLSYGAFPDIANDFGEKSLLMPGGAVINGDFNNVLPVDLVDPQQVQEFVDHAWYRYPNDQVGRHPFDGITDPWYNPGDVKGSDTNIQQLNEQERYSWIKAPRWRGNAMEVGPLARTLIAYHKGDAATVESVDRMMSALNLPLSGIQSTLGRILCRAHEAQWAAGKLQYFFDKLMTNLKNGNLATASTEKWEPATWPTECRGVGFTEAPRGALGHWAAIRDGKIDLYQCVVPTTWNASPRDPKGQIGAYEAALMNTKMAIPEQPLEILRTLHSFDPCLACSTH
69 -> 69 W

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.6 - aerobic respiration
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.1 - electron donors
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0044569 - [Ni-Fe] hydrogenase complex
molecular_function GO:0005515 - protein binding
GO:0009055 - electron transfer activity
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0016151 - nickel cation binding
GO:0008901 - ferredoxin hydrogenase activity
GO:0033748 - hydrogenase (acceptor) activity
biological_process GO:0006113 - fermentation
GO:0009061 - anaerobic respiration
GO:0019645 - anaerobic electron transport chain
GO:0022900 - electron transport chain
GO:0055114 - oxidation-reduction process
GO:1902421 - hydrogen metabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Przybyla AE., et al., 1992
External database links:  
DIP:
DIP-36180N
ECOCYC:
HYAB-MONOMER
ECOLIWIKI:
b0973
INTERPRO:
IPR001501
INTERPRO:
IPR018194
INTERPRO:
IPR029014
MODBASE:
P0ACD8
PDB:
5A4M
PDB:
5ADU
PDB:
5JRD
PDB:
5LMM
PDB:
6FPI
PDB:
6FPO
PDB:
6FPW
PDB:
6G7R
PDB:
6G94
PDB:
6GAL
PDB:
5A4I
PDB:
5A4F
PDB:
4UE3
PDB:
4GD3
PDB:
3USE
PDB:
3USC
PDB:
3UQY
PDB:
5LRY
PFAM:
PF00374
PRIDE:
P0ACD8
PRODB:
PRO_000022944
PROSITE:
PS00508
PROSITE:
PS00507
REFSEQ:
NP_415492
SMR:
P0ACD8
UNIPROT:
P0ACD8


Operon      
Name: hyaABCDEF         
Operon arrangement:
Transcription unit        Promoter
hyaABCDEF


Transcriptional Regulation      
Display Regulation             
Activated by: ArcA, YdeO, AppY
Repressed by: IscR, NarL, NarP, Fis


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Przybyla AE., Robbins J., Menon N., Peck HD., 1992, Structure-function relationships among the nickel-containing hydrogenases., FEMS Microbiol Rev 8(2):109-35


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