RegulonDB RegulonDB 10.7: Gene Form
   

kdsA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

kdsA ychA ldrA kdsAp kdsAp

Gene      
Name: kdsA    Texpresso search in the literature
Synonym(s): ECK1203, EG10518, b1215
Genome position(nucleotides): 1268165 --> 1269019 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.58
External database links:  
ASAP:
ABE-0004077
CGSC:
17671
ECHOBASE:
EB0513
OU-MICROARRAY:
b1215
PORTECO:
kdsA
REGULONDB:
b1215
STRING:
511145.b1215
M3D: kdsA
COLOMBOS: kdsA
PortEco: b1215


Shine dalgarno      
Sequence: cattttactcAAGATTaaggcgatcctATG


Product      
Name: 3-deoxy-D-manno-octulosonate 8-phosphate synthase
Synonym(s): KdsA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 30.833
Isoelectric point: 6.795
Motif(s):
 
Type Positions Sequence
10 -> 274 DINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKIITDVHEPSQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFKEGGNEKVILCDRGANFGYDNLVVDMLGFSIMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEAHPDPEHAKCDGPSALPLAKLEPFLKQMKAIDDLV
22 -> 22 F

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.3 - lipopolysaccharide --> 1.6.3.2 - core region
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0008676 - 3-deoxy-8-phosphooctulonate synthase activity
GO:0042802 - identical protein binding
biological_process GO:0009058 - biosynthetic process
GO:0009103 - lipopolysaccharide biosynthetic process
GO:0019294 - keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [1] Tolbert WD., et al., 1996
[2] Woisetschlager M., et al., 1986
External database links:  
DIP:
DIP-35940N
ECOCYC:
KDO-8PSYNTH-MONOMER
ECOLIWIKI:
b1215
INTERPRO:
IPR006269
INTERPRO:
IPR006218
INTERPRO:
IPR013785
MINT:
MINT-1220797
MODBASE:
P0A715
PANTHER:
PTHR21057
PDB:
1X8F
PDB:
1X6U
PDB:
1Q3N
PDB:
1PL9
PDB:
1PHW
PDB:
1PHQ
PDB:
1GG0
PDB:
1G7V
PDB:
1G7U
PDB:
1D9E
PFAM:
PF00793
PRIDE:
P0A715
PRODB:
PRO_000023054
PROTEINMODELPORTAL:
P0A715
REFSEQ:
NP_415733
SMR:
P0A715
UNIPROT:
P0A715


Operon      
Name: ychQA-kdsA         
Operon arrangement:
Transcription unit        Promoter
ychQA-kdsA
kdsA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Tolbert WD., Moll JR., Bauerle R., Kretsinger RH., 1996, Crystallization and preliminary crystallographic studies of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli., Proteins 24(3):407-8

 [2] Woisetschlager M., Hogenauer G., 1986, Cloning and characterization of the gene encoding 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli., J Bacteriol 168(1):437-9


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