RegulonDB RegulonDB 10.8: Gene Form
   

manX gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

manX manY yoaL yoaE Cra NagC Mlc CRP Mlc NagC CRP TSS_2168 TSS_2168 TSS_2167 TSS_2167 TSS_2166 TSS_2166 TSS_2165 (cluster) TSS_2165 (cluster) TSS_2164 TSS_2164 TSS_2163 TSS_2163 TSS_2162 TSS_2162 TSS_2161 TSS_2161 TSS_2160 (cluster) TSS_2160 (cluster) TSS_2159 TSS_2159 TSS_2158 TSS_2158 TSS_2157 TSS_2157 TSS_2156 (cluster) TSS_2156 (cluster) TSS_2155 TSS_2155 TSS_2154 TSS_2154 TSS_2153 TSS_2153 TSS_2152 TSS_2152 TSS_2151 TSS_2151 TSS_2150 TSS_2150 TSS_2149 TSS_2149 TSS_2148 TSS_2148 TSS_2147 (cluster) TSS_2147 (cluster) TSS_2146 TSS_2146 TSS_2145 TSS_2145 TSS_2144 TSS_2144 TSS_2143 TSS_2143 TSS_2142 (cluster) TSS_2142 (cluster) manXp manXp yoaEp yoaEp TSS_2140 TSS_2140

Gene      
Name: manX    Texpresso search in the literature
Synonym(s): ECK1815, EG10567, b1817, gptB, mpt, ptsL, ptsM, ptsX
Genome position(nucleotides): 1902048 --> 1903019 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.31
External database links:  
ASAP:
 ABE-0006054
CGSC:
 17656
ECHOBASE:
 EB0562
OU-MICROARRAY:
 b1817
PortEco:
 manX
STRING:
 511145.b1817
COLOMBOS: manX


Product      
Name: mannose-specific PTS enzyme IIAB component
Synonym(s): Enzyme IIABman, Enzyme IIIman, GptB, IIIMan, ManX, Mpt, PtsL, PtsM, PtsX
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,cytosol
Molecular weight: 35.048
Isoelectric point: 5.817
Motif(s):
 
Type Positions Sequence
10 -> 10 H
137 -> 155 AAPAPAAAAPKAAPTPAKP
2 -> 23 TIAIVIGTHGWAAEQLLKTAEM
12 -> 12 W
48 -> 48 K

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.4 - Group Translocators --> 4.4.A - Phosphotransferase Systems (PEP-dependent PTS)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0016301 - kinase activity
GO:0016773 - phosphotransferase activity, alcohol group as acceptor
GO:0008982 - protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0042803 - protein homodimerization activity
GO:0022870 - protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
biological_process GO:0098708 - glucose import across plasma membrane
GO:0008643 - carbohydrate transport
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0016310 - phosphorylation
GO:0015764 - N-acetylglucosamine transport
GO:0015761 - mannose transmembrane transport
GO:0032445 - fructose import
Note(s): Note(s): ...[more].
External database links:  
DIP:
 DIP-35846N
ECOCYC:
 MANX-MONOMER
ECOLIWIKI:
 b1817
INTERPRO:
 IPR004701
INTERPRO:
 IPR036667
INTERPRO:
 IPR036662
INTERPRO:
 IPR033887
INTERPRO:
 IPR018455
INTERPRO:
 IPR013789
INTERPRO:
 IPR004720
MINT:
 P69797
PDB:
 2JZO
PDB:
 1PDO
PDB:
 2JZH
PDB:
 2JZN
PDB:
 1VRC
PDB:
 1VSQ
PFAM:
 PF03830
PFAM:
 PF03610
PRIDE:
 P69797
PRODB:
 PRO_000023161
PROSITE:
 PS51101
PROSITE:
 PS51096
REFSEQ:
 NP_416331
SMR:
 P69797
SWISSMODEL:
 P69797
UNIPROT:
 P69797


Operon      
Name: manXYZ         
Operon arrangement:
Transcription unit        Promoter
manXYZ


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: NagC, Mlc, Cra


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2140 1901769 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2142 (cluster) 1901934 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_2143 1902030 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2144 1902032 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2145 1902072 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2146 1902618 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2147 (cluster) 1903044 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_2148 1903052 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2149 1903059 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2150 1903166 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2151 1903202 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2152 1903244 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2153 1903321 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2154 1903409 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2155 1903587 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2156 (cluster) 1903744 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_2157 1903789 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2158 1903802 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2159 1903806 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2160 (cluster) 1903812 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_2161 1903815 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2162 1903818 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2163 1903821 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2164 1903823 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2165 (cluster) 1903860 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_2166 1903863 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2167 1903867 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2168 1903873 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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