RegulonDB

RegulonDB RegulonDB 10.8: Gene Form

mazG gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	mazG
Synonym(s):	ECK2775, EG10572, b2781
Genome position(nucleotides):	2909894 <-- 2910685 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.76
External database links:

ASAP:	ABE-0009117
ECHOBASE:	EB0567
OU-MICROARRAY:	b2781
PortEco:	mazG
STRING:	511145.b2781
COLOMBOS:	mazG

Product

Name:

nucleoside triphosphate pyrophosphohydrolase

Synonym(s):

MazG

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

30.412

Isoelectric point:

4.393

Motif(s):

Type	Positions	Sequence
	175 -> 175	E
	27 -> 100	QTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVF
	168 -> 168	K
	189 -> 189	K
	226 -> 226	R

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.5 - adaptations --> 5.5.3 - starvation
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0005515 - protein binding GO:0016787 - hydrolase activity GO:0046872 - metal ion binding GO:0047429 - nucleoside-triphosphate diphosphatase activity GO:0000166 - nucleotide binding GO:0005524 - ATP binding GO:0047693 - ATP diphosphatase activity
	biological_process	GO:0009267 - cellular response to starvation GO:0006203 - dGTP catabolic process GO:0046081 - dUTP catabolic process GO:0046047 - TTP catabolic process GO:0046052 - UTP catabolic process GO:0046061 - dATP catabolic process GO:0046076 - dTTP catabolic process

Note(s):

Note(s): ...[more].

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

MINT:

PANTHER:

PDB:

PDB:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

relA-mazEFG

Operon arrangement:

Transcription unit	Promoter
mazEFG	mazEp2
mazEFG	mazEp1
relA	relAp3
relA-mazEF	relAp1
relA-mazEF	relAp2
relA	relAp4

Transcriptional Regulation
	Display Regulation
Activated by:	Fis
Repressed by:	MazE, MazE-MazF

RNA cis-regulatory element

Attenuation:	Translational

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_3074 (cluster)	2908226	reverse	For this promoter, there is a cluster of 2 transcription start sites,in the interval 2908225 to 2908226, where the highest frequency is at position 2906247. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
promoter	TSS_3075	2908550	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_3076	2908879	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_3077	2908881	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_3078	2909694	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_3079	2909704	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_3080	2909706	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_3081	2909711	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_3082 (cluster)	2909716	reverse	For this promoter, there is a cluster of 4 transcription start sites,in the interval 2909713 to 2909716, where the highest frequency is at position 2907735. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
promoter	TSS_3083 (cluster)	2909795	reverse	For this promoter, there is a cluster of 2 transcription start sites,in the interval 2909794 to 2909795, where the highest frequency is at position 2907816. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
promoter	mazGp4	2910860	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.735. P-value: 5.947e-5 Read more >	[ICWHO]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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