RegulonDB RegulonDB 10.6.3: Gene Form
   

mreD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mreC mreB yhdE mreD rng TSS_3582 TSS_3582 TSS_3581 TSS_3581 TSS_3580 TSS_3580 TSS_3579 TSS_3579 mreDp2 mreDp2

Gene      
Name: mreD    Texpresso search in the literature
Synonym(s): ECK3237, EG10610, b3249
Genome position(nucleotides): 3398387 <-- 3398875 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.33
External database links:  
ASAP:
ABE-0010656
CGSC:
31351
ECHOBASE:
EB0605
ECOCYC:
EG10610
ECOLIHUB:
mreD
OU-MICROARRAY:
b3249
REGULONDB:
b3249
STRING:
511145.b3249
M3D: mreD
COLOMBOS: mreD
PortEco: b3249


Product      
Name: cell shape determining protein MreD
Synonym(s): MreD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 18.788
Isoelectric point: 10.979
Motif(s):
 
Type Positions Sequence
106 -> 126 VVMLLSLVVDIIVFWAEFLVI
68 -> 90 LISGSTLGVRVLAMSIIAYLVAL
132 -> 152 PEVFWSSVVNGVLWPWIFLLM
56 -> 76 VGTGFVMGAILDLISGSTLGV
5 -> 155 RSQGRWVIWLSFLIALLLQIMPWPDNLIVFRPNWVLLILLYWILALPHRVNVGTGFVMGAILDLISGSTLGVRVLAMSIIAYLVALKYQLFRNLALWQQALVVMLLSLVVDIIVFWAEFLVINVSFRPEVFWSSVVNGVLWPWIFLLMRKV

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
biological_process GO:0008360 - regulation of cell shape
Note(s): Note(s): ...[more].
Evidence: [IGI] Inferred from genetic interaction
[IMP] Inferred from mutant phenotype
Reference(s): [1] Bendezu FO., et al., 2008
[2] Kruse T., et al., 2005
[3] Wachi M., et al., 1989
External database links:  
DIP:
DIP-10257N
ECOCYC:
EG10610-MONOMER
ECOLIWIKI:
b3249
INTERPRO:
IPR007227
INTERPRO:
IPR026034
PANTHER:
PTHR37484
PFAM:
PF04093
PRIDE:
P0ABH4
PRODB:
PRO_000023291
PROTEINMODELPORTAL:
P0ABH4
REFSEQ:
NP_417715
UNIPROT:
P0ABH4


Operon      
Name: mreBCD         
Operon arrangement:
Transcription unit        Promoter
mreB
mreBCD
mreB
mreBCD
mreB
mreBCD
mreCD


Transcriptional Regulation      
Display Regulation             
Repressed by: BolA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter mreDp2 3399083 reverse Similarity to the consensus
Read more >
[ICWHO] [4]
  promoter TSS_3579 3399805 reverse nd [RS-EPT-CBR] [5]
  promoter TSS_3580 3400666 reverse nd [RS-EPT-CBR] [5]
  promoter TSS_3581 3400674 reverse nd [RS-EPT-CBR] [5]
  promoter TSS_3582 3401076 reverse nd [RS-EPT-CBR] [5]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Bendezu FO., de Boer PA., 2008, Conditional lethality, division defects, membrane involution, and endocytosis in mre and mrd shape mutants of Escherichia coli., J Bacteriol 190(5):1792-811

 [2] Kruse T., Bork-Jensen J., Gerdes K., 2005, The morphogenetic MreBCD proteins of Escherichia coli form an essential membrane-bound complex., Mol Microbiol 55(1):78-89

 [3] Wachi M., Doi M., Okada Y., Matsuhashi M., 1989, New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells., J Bacteriol 171(12):6511-6

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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