RegulonDB RegulonDB 10.8: Gene Form
   

mrp gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

metG mrp yehE anti-anti-terminator anti-terminator terminator terminator metGp metGp TSS_2441 TSS_2441 mrpp mrpp TSS_2440 (cluster) TSS_2440 (cluster) TSS_2439 (cluster) TSS_2439 (cluster) TSS_2438 TSS_2438 mrpp7 mrpp7 mrpp2 mrpp2 metGp2 metGp2 yehEp1 yehEp1 yehEp8 yehEp8 yehEp7 yehEp7 TSS_2437 TSS_2437

Gene      
Name: mrp    Texpresso search in the literature
Synonym(s): ECK2106, EG10611, b2113
Genome position(nucleotides): 2193059 <-- 2194168 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.96
External database links:  
ASAP:
ABE-0006987
ECHOBASE:
EB0606
MIM:
252010
OU-MICROARRAY:
b2113
PortEco:
mrp
STRING:
511145.b2113
COLOMBOS: mrp


Product      
Name: P-loop NTPase family protein Mrp
Synonym(s): Mrp
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 39.938
Isoelectric point: 6.275
Motif(s):
 
Type Positions Sequence
106 -> 349 VKNIIAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLGAENQRPTSPDGTHMAPIMSHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSVHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDKGTPTVISRPESEFTAIYRQLADRV
115 -> 122 GKGGVGKS

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016787 - hydrolase activity
GO:0016887 - ATPase activity
GO:0046872 - metal ion binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0051536 - iron-sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
biological_process GO:0016226 - iron-sulfur cluster assembly
Note(s): Note(s): ...[more].
Reference(s): [1] Dardel F., et al., 1991
[2] Gerard E., et al., 1998
[3] High NJ., et al., 1996
External database links:  
ECOCYC:
EG10611-MONOMER
ECOLIWIKI:
b2113
INTERPRO:
IPR000808
INTERPRO:
IPR034904
INTERPRO:
IPR033756
INTERPRO:
IPR027417
INTERPRO:
IPR019591
MODBASE:
P0AF08
PANTHER:
PTHR23264
PFAM:
PF10609
PRIDE:
P0AF08
PRODB:
PRO_000023292
PROSITE:
PS01215
REFSEQ:
NP_416616
SMR:
P0AF08
UNIPROT:
P0AF08


Operon      
Name: mrp         
Operon arrangement:
Transcription unit        Promoter
mrp


RNA cis-regulatory element    
Attenuation: Translational


Regulation by small RNA    
  Display Regulation
small RNA ryhB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2437 2192686 forward nd [RS-EPT-CBR] [4]
  promoter yehEp7 2192880 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter yehEp8 2192901 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter yehEp1 2192909 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter mrpp2 2194175 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter mrpp7 2194180 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter TSS_2438 2194185 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_2439 (cluster) 2194194 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [4]
  promoter TSS_2440 (cluster) 2194200 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [4]
  promoter TSS_2441 2194222 reverse nd [RS-EPT-CBR] [4]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Dardel F., Panvert M., Blanquet S., Fayat G., 1991, Locations of the metG and mrp genes on the physical map of Escherichia coli., J Bacteriol 173(11):3273

 [2] Gerard E., Labedan B., Forterre P., 1998, Isolation of a minD-like gene in the hyperthermophilic archaeon Pyrococcus AL585, and phylogenetic characterization of related proteins in the three domains of life., Gene 222(1):99-106

 [3] High NJ., Deadman ME., Hood DW., Moxon ER., 1996, The identification a novel gene required for lipopolysaccharide biosynthesis by Haemophilus influenzae RM7004, using transposon Tn916 mutagenesis., FEMS Microbiol Lett 145(3):325-31

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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