RegulonDB RegulonDB 10.8: Gene Form
   

mtr gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

deaD mtr yhbW yrbN TyrR TyrR TrpR TrpR anti-anti-terminator anti-terminator terminator TSS_3434 TSS_3434 TSS_3433 TSS_3433 TSS_3432 TSS_3432 mtrp1 mtrp1 mtrp2 mtrp2

Gene      
Name: mtr    Texpresso search in the literature
Synonym(s): ECK3149, EG10617, b3161
Genome position(nucleotides): 3304573 <-- 3305817 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.09
External database links:  
ASAP:
ABE-0010387
CGSC:
478
ECHOBASE:
EB0612
OU-MICROARRAY:
b3161
PortEco:
mtr
STRING:
511145.b3161
COLOMBOS: mtr


Shine dalgarno      
Sequence: ttttcactggAGAGAAgccctCAT


Product      
Name: tryptophan:H+ symporter Mtr
Synonym(s): Mtr, Mtr tryptophan ArAAP transporter
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 44.333
Isoelectric point: 9.706
Motif(s):
 
Type Positions Sequence
152 -> 174 MTAIVLGAKVITFFLTFGSLLGH
189 -> 210 SYAPYLLMTLPFCLASFGYHGN
322 -> 343 RLKTALLTFAPPVVGGLLFPNG
344 -> 365 FLYAIGYAGLAATIWAAIVPAL
387 -> 409 MIALILVFGVGNALVHILSSFNL

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.15 - tryptophan
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0022804 - active transmembrane transporter activity
GO:0015173 - aromatic amino acid transmembrane transporter activity
GO:0005300 - high-affinity tryptophan transmembrane transporter activity
biological_process GO:0006865 - amino acid transport
GO:0015801 - aromatic amino acid transport
GO:0015827 - tryptophan transport
GO:0003333 - amino acid transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
MTR-MONOMER
ECOLIWIKI:
b3161
INTERPRO:
IPR013061
INTERPRO:
IPR018227
INTERPRO:
IPR013059
PANTHER:
PTHR46997
PFAM:
PF03222
PRIDE:
P0AAD2
PRINTS:
PR00166
PRODB:
PRO_000023307
PROSITE:
PS00594
REFSEQ:
NP_417630
UNIPROT:
P0AAD2


Operon      
Name: mtr         
Operon arrangement:
Transcription unit        Promoter
mtr
mtr


Transcriptional Regulation      
Display Regulation             
Activated by: TyrR
Repressed by: IHF, HU, TrpR


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3432 3307002 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3433 3307564 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3434 3307652 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


RegulonDB