RegulonDB RegulonDB 10.8: Gene Form
   

nagA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

nagC nagA nagB PhoP terminator nagAp nagAp TSS_801 TSS_801 nagCp2 nagCp2 nagCp1 nagCp1 TSS_799 TSS_799 TSS_798 TSS_798 TSS_797 TSS_797 TSS_796 TSS_796 TSS_795 TSS_795 TSS_794 TSS_794 TSS_793 TSS_793

Gene      
Name: nagA    Texpresso search in the literature
Synonym(s): ECK0665, EG10632, b0677
Genome position(nucleotides): 701603 <-- 702751 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.78
External database links:  
ASAP:
 ABE-0002301
CGSC:
 464
ECHOBASE:
 EB0626
OU-MICROARRAY:
 b0677
PortEco:
 nagA
STRING:
 511145.b0677
COLOMBOS: nagA


Product      
Name: N-acetylglucosamine-6-phosphate deacetylase
Synonym(s): NagA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 40.949
Isoelectric point: 5.842
Motif(s):
 
Type Positions Sequence
143 -> 143 H
306 -> 308 LSG
59 -> 59 Q
131 -> 131 E
248 -> 251 DGLH

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.12 - amino sugar conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0008270 - zinc ion binding
GO:0008448 - N-acetylglucosamine-6-phosphate deacetylase activity
GO:0042802 - identical protein binding
GO:0047419 - N-acetylgalactosamine-6-phosphate deacetylase activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0006044 - N-acetylglucosamine metabolic process
GO:0006046 - N-acetylglucosamine catabolic process
GO:0019262 - N-acetylneuraminate catabolic process
GO:0051289 - protein homotetramerization
Note(s): Note(s): ...[more].
External database links:  
DIP:
 DIP-10297N
ECOCYC:
 NAG6PDEACET-MONOMER
ECOLIWIKI:
 b0677
INTERPRO:
 IPR003764
INTERPRO:
 IPR032466
INTERPRO:
 IPR011059
INTERPRO:
 IPR006680
MODBASE:
 P0AF18
PANTHER:
 PTHR11113:SF1
PDB:
 2P50
PDB:
 1YRR
PDB:
 1YMY
PDB:
 2P53
PFAM:
 PF01979
PRIDE:
 P0AF18
PRODB:
 PRO_000023336
REFSEQ:
 NP_415203
SMR:
 P0AF18
SWISSMODEL:
 P0AF18
UNIPROT:
 P0AF18


Operon      
Name: nagBAC-umpH         
Operon arrangement:
Transcription unit        Promoter
umpH
nagC
nagC
nagA
nagBACD


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, PhoP
Repressed by: CRP, NagC


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_793 701039 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_794 701340 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_795 701360 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_796 701362 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_797 701364 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_798 701606 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_799 701647 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_801 702710 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB