RegulonDB

RegulonDB RegulonDB 10.8: Gene Form

pabB gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	pabB
Synonym(s):	ECK1810, EG10683, b1812
Genome position(nucleotides):	1894805 --> 1896166 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.95
External database links:

ASAP:	ABE-0006031
CGSC:	428
ECHOBASE:	EB0677
OU-MICROARRAY:	b1812
PortEco:	pabB
STRING:	511145.b1812
COLOMBOS:	pabB

Product

Name:

aminodeoxychorismate synthase subunit 1

Synonym(s):

ADC synthase, PabB, aminodeoxychorismate synthase component 1, para-aminobenzoate synthase component I

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

50.97

Isoelectric point:

4.876

Motif(s):

Type	Positions	Sequence
	275 -> 275	G
	316 -> 316	R
	339 -> 339	H
	240 -> 242	PFS
	22 -> 153	FSRLSHLPWAMLLHSGYADHPYSRFDIVVAEPICTLTTFGKETVVSESEKRTTTTDDPLQVLQQVLDRADIRPTHNEDLPFQGGALGLFGYDLGRRFESLPEIAEQDIVLPDMAVGIYDWALIVDHQRHTVS

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.2 - folic acid
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0016740 - transferase activity GO:0046820 - 4-amino-4-deoxychorismate synthase activity GO:0000287 - magnesium ion binding
	biological_process	GO:0009058 - biosynthetic process GO:0009396 - folic acid-containing compound biosynthetic process GO:0046656 - folic acid biosynthetic process GO:0046654 - tetrahydrofolate biosynthetic process

Note(s):

Note(s): ...[more].

External database links:

DIP:

DIP-10434N

ECOCYC:

PABASYN-COMPI-MONOMER

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PFAM:

PFAM:

PRIDE:

PRINTS:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

pabB-nudL

Operon arrangement:

Transcription unit	Promoter

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	pabBp7	1894628	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 8.983. P-value: 1.006e-6 Read more >	[ICWHO]	[1]
promoter	TSS_2136	1894757	forward	nd	[RS-EPT-CBR]	[2]
promoter	pabBp6	1894779	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 7.21. P-value: 2.283e-6 Read more >	[ICWHO]	[1]
promoter	yoaHp1	1894933	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: -1.66. P-value: 6.206e-6 Read more >	[ICWHO]	[1]
promoter	TSS_2137	1896141	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_2138	1896143	forward	nd	[RS-EPT-CBR]	[2]

Evidence
[ICWHO] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB