RegulonDB RegulonDB 10.7: Gene Form
   

pcm gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

nlpD truD umpG pcm ispF MqsA ArcA CRP ArcA CRP DsrA RprA ArcZ DksA-ppGpp DksA-ppGpp ppGpp surEp2 surEp2 nlpDp1 nlpDp1 nlpDp2 nlpDp2 TSS_3034 TSS_3034 rpoSp rpoSp rpoSp4 rpoSp4 rpoSp3 rpoSp3 TSS_3032 TSS_3032

Gene      
Name: pcm    Texpresso search in the literature
Synonym(s): ECK2738, EG10689, b2743
Genome position(nucleotides): 2868893 <-- 2869519 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.43
External database links:  
ASAP:
 ABE-0009006
CGSC:
 33221
ECHOBASE:
 EB0683
OU-MICROARRAY:
 b2743
PORTECO:
 pcm
REGULONDB:
 b2743
STRING:
 511145.b2743
M3D: pcm
COLOMBOS: pcm
PortEco: b2743


Product      
Name: L-isoaspartate protein carboxylmethyltransferase type II
Synonym(s): Pcm
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 23.258
Isoelectric point: 7.073
Motif(s):
 
Type Positions Sequence
2 -> 208 VSRRVQALLDQLRAQGIQDEQVLNALAAVPREKFVDEAFEQKAWDNIALPIGQGQTISQPYMVARMTELLELTPQSRVLEIGTGSGYQTAILAHLVQHVCSVERIKGLQWQARRRLKNLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPPEIPTALMTQLDEGGILVLPVGEEHQYLKRVRRRGGEFIIDTVEAVRFVPLVKGELA
5 -> 206 RVQALLDQLRAQGIQDEQVLNALAAVPREKFVDEAFEQKAWDNIALPIGQGQTISQPYMVARMTELLELTPQSRVLEIGTGSGYQTAILAHLVQHVCSVERIKGLQWQARRRLKNLDLHNVSTRHGDGWQGWQARAPFDAIIVTAAPPEIPTALMTQLDEGGILVLPVGEEHQYLKRVRRRGGEFIIDTVEAVRFVPLVKGE

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0008168 - methyltransferase activity
GO:0016740 - transferase activity
GO:0004719 - protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
biological_process GO:0006464 - cellular protein modification process
GO:0006479 - protein methylation
GO:0030091 - protein repair
GO:0032259 - methylation
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 EG10689-MONOMER
ECOLIWIKI:
 b2743
INTERPRO:
 IPR029063
INTERPRO:
 IPR000682
MODBASE:
 P0A7A5
PANTHER:
 PTHR11579
PDB:
 3LBF
PFAM:
 PF01135
PRIDE:
 P0A7A5
PRODB:
 PRO_000023499
PROSITE:
 PS01279
PROTEINMODELPORTAL:
 P0A7A5
REFSEQ:
 NP_417223
SMR:
 P0A7A5
SWISSMODEL:
 P0A7A5
UNIPROT:
 P0A7A5


Operon      
Name: umpG-pcm         
Operon arrangement:
Transcription unit        Promoter
umpG-pcm


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3032 2867645 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3034 2868128 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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