RegulonDB RegulonDB 10.7: Gene Form
   

pgpB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pgpB ribA lapA SoxS TSS_1726 TSS_1726 TSS_1725 (cluster) TSS_1725 (cluster) lapAp2 lapAp2 lapAp1 lapAp1 pgpBp pgpBp pgpBp7 pgpBp7 pgpBp4 pgpBp4 ribAp2 ribAp2 pgpBp5 pgpBp5 TSS_1724 TSS_1724 ribAp1 ribAp1 TSS_1722 TSS_1722 pgpBp8 pgpBp8 pgpBp9 pgpBp9 pgpBp6 pgpBp6

Gene      
Name: pgpB    Texpresso search in the literature
Synonym(s): ECK1273, EG10705, b1278
Genome position(nucleotides): 1339330 --> 1340094 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.59
External database links:  
ASAP:
ABE-0004294
CGSC:
17641
ECHOBASE:
EB0699
OU-MICROARRAY:
b1278
PORTECO:
pgpB
REGULONDB:
b1278
STRING:
511145.b1278
M3D: pgpB
COLOMBOS: pgpB
PortEco: b1278


Product      
Name: phosphatidylglycerophosphatase B
Synonym(s): PgpB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,outer membrane
Molecular weight: 29.021
Isoelectric point: 10.804
Motif(s):
 
Type Positions Sequence
183 -> 202 RTLTIAILLVWATGVMGSRL
55 -> 66 ITHLILFGWFLW
162 -> 176 GHTMFAASWALLAVG
209 -> 232 PRDLVVATLISWALVAVATWLAQR
2 -> 24 RSIARRTAVGAALLLVMPVAVWI

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.1 - phospholipid
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.7 - murein (peptidoglycan)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0009279 - cell outer membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016787 - hydrolase activity
GO:0008962 - phosphatidylglycerophosphatase activity
GO:0050380 - undecaprenyl-diphosphatase activity
GO:0000810 - diacylglycerol diphosphate phosphatase activity
GO:0008195 - phosphatidate phosphatase activity
biological_process GO:0006629 - lipid metabolic process
GO:0009252 - peptidoglycan biosynthetic process
GO:0046474 - glycerophospholipid biosynthetic process
GO:0016311 - dephosphorylation
GO:0016042 - lipid catabolic process
GO:0009395 - phospholipid catabolic process
GO:0006655 - phosphatidylglycerol biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
PGPPHOSPHAB-MONOMER
ECOLIWIKI:
b1278
INTERPRO:
IPR000326
INTERPRO:
IPR036938
MODBASE:
P0A924
PDB:
4PX7
PDB:
5JWY
PFAM:
PF01569
PRIDE:
P0A924
PRODB:
PRO_000023526
PROTEINMODELPORTAL:
P0A924
REFSEQ:
NP_415794
SMART:
SM00014
SMR:
P0A924
UNIPROT:
P0A924


Operon      
Name: pgpB         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter pgpBp6 1339162 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter pgpBp9 1339165 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter pgpBp8 1339182 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_1722 1339188 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1724 1339192 reverse nd [RS-EPT-CBR] [2]
  promoter pgpBp5 1339193 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter pgpBp4 1339235 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter pgpBp7 1339308 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_1725 (cluster) 1340187 forward For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_1726 1340213 forward nd [RS-EPT-CBR] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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