RegulonDB RegulonDB 10.8: Gene Form
   

potC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

potA potD potB potC ymfA ycfZ terminator TSS_1462 (cluster) TSS_1462 (cluster) TSS_1461 TSS_1461 TSS_1460 TSS_1460 TSS_1459 TSS_1459 TSS_1458 TSS_1458 potDp6 potDp6 potDp5 potDp5 TSS_1457 TSS_1457 TSS_1456 TSS_1456 ycfZp5 ycfZp5 ycfZp6 ycfZp6

Gene      
Name: potC    Texpresso search in the literature
Synonym(s): ECK1110, EG10751, b1124
Genome position(nucleotides): 1182826 <-- 1183620 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.19
External database links:  
ASAP:
ABE-0003791
CGSC:
31905
ECHOBASE:
EB0744
OU-MICROARRAY:
b1124
PortEco:
potC
STRING:
511145.b1124
COLOMBOS: potC


Product      
Name: spermidine preferential ABC transporter membrane subunit PotC
Synonym(s): PotC
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 29.111
Isoelectric point: 10.087
Motif(s):
 
Type Positions Sequence
60 -> 248 AQHSLTMAVFSATFATLIGSLTAVALYRYRFRGKPFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFSHITFCLPFVVVTVYSRLKGFDVRMLEAAKDLGASEFTILRKIILPLAMPAVAAGWVLSFTLSMDDVVVSSFVTGPSYEILPLKIYSMVKVGVSPEVNALATILLVLSLVMVIAS
75 -> 253 TLIGSLTAVALYRYRFRGKPFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFSHITFCLPFVVVTVYSRLKGFDVRMLEAAKDLGASEFTILRKIILPLAMPAVAAGWVLSFTLSMDDVVVSSFVTGPSYEILPLKIYSMVKVGVSPEVNALATILLVLSLVMVIASQLIAR
66 -> 85 MAVFSATFATLIGSLTAVAL
177 -> 196 ILPLAMPAVAAGWVLSFTLS
8 -> 27 GGFMTAIYAYLYIPIIILIV

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.4 - amines
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
molecular_function GO:0015595 - ATPase-coupled spermidine transmembrane transporter activity
biological_process GO:0055085 - transmembrane transport
GO:0015847 - putrescine transport
GO:1903711 - spermidine transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
DIP:
DIP-48152N
ECOCYC:
POTC-MONOMER
ECOLIWIKI:
b1124
INTERPRO:
IPR000515
INTERPRO:
IPR035906
MINT:
MINT-1315836
PFAM:
PF00528
PRIDE:
P0AFK6
PRODB:
PRO_000023569
PROSITE:
PS50928
REFSEQ:
NP_415642
SMR:
P0AFK6
UNIPROT:
P0AFK6


Operon      
Name: potABCD         
Operon arrangement:
Transcription unit        Promoter
potABCD


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ycfZp6 1181346 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter ycfZp5 1181380 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_1456 1182741 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_1457 1182847 reverse nd [RS-EPT-CBR] [3]
  promoter potDp5 1182848 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter potDp6 1182850 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_1458 1182851 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_1459 1182909 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_1460 1182913 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_1461 1182965 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_1462 (cluster) 1182969 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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