RegulonDB RegulonDB 10.7: Gene Form
   

pyrG gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pyrG eno mazG Cra Cra anti-anti-terminator anti-terminator terminator pyrGp1 pyrGp1 TSS_3083 (cluster) TSS_3083 (cluster) pyrGp2 pyrGp2 TSS_3082 (cluster) TSS_3082 (cluster) pyrGp pyrGp TSS_3081 TSS_3081 TSS_3080 TSS_3080 TSS_3079 TSS_3079 TSS_3078 TSS_3078 TSS_3077 TSS_3077 TSS_3076 TSS_3076 enop3 enop3 enop2 enop2 enop1 enop1 TSS_3075 TSS_3075 TSS_3074 (cluster) TSS_3074 (cluster) enop7 enop7 TSS_3073 (cluster) TSS_3073 (cluster) enop6 enop6 TSS_3072 (cluster) TSS_3072 (cluster) enop4 enop4 TSS_3070 TSS_3070 TSS_3069 TSS_3069 TSS_3068 TSS_3068 TSS_3067 TSS_3067 TSS_3066 TSS_3066 TSS_3065 TSS_3065 TSS_3064 (cluster) TSS_3064 (cluster) TSS_3063 TSS_3063 TSS_3062 TSS_3062 TSS_3061 TSS_3061 TSS_3060 TSS_3060 TSS_3059 TSS_3059 TSS_3058 (cluster) TSS_3058 (cluster) TSS_3057 (cluster) TSS_3057 (cluster) TSS_3056 TSS_3056 TSS_3055 TSS_3055

Gene      
Name: pyrG    Texpresso search in the literature
Synonym(s): ECK2774, EG10810, b2780
Genome position(nucleotides): 2908029 <-- 2909666 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.89
External database links:  
ASAP:
ABE-0009112
CGSC:
325
ECHOBASE:
EB0803
MIM:
615897
OU-MICROARRAY:
b2780
PORTECO:
pyrG
REGULONDB:
b2780
STRING:
511145.b2780
M3D: pyrG
COLOMBOS: pyrG
PortEco: b2780


Product      
Name: CTP synthetase
Synonym(s): CTP synthase, PyrG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 60.374
Isoelectric point: 5.779
Motif(s):
 
Type Positions Sequence
301 -> 535 LPDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPGGFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANSTEFVPDCKYPVVALITEWRDENGNVEVRSEKSDLGGTMRLGAQQCQLVDDSLVRQLYNAPTIVERHRHRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEFTSTPRDGHPLFAGFVKA
147 -> 149 DIE
349 -> 349 V
380 -> 383 LGMQ
476 -> 476 M

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.2 - nucleotides --> 1.5.2.4 - pyrimidine ribonucleotide biosynthesis
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.33 - nucleotide and nucleoside conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0046872 - metal ion binding
GO:0016874 - ligase activity
GO:0003883 - CTP synthase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0000287 - magnesium ion binding
GO:0042802 - identical protein binding
biological_process GO:0006221 - pyrimidine nucleotide biosynthetic process
GO:0006541 - glutamine metabolic process
GO:0006241 - CTP biosynthetic process
GO:0019856 - pyrimidine nucleobase biosynthetic process
GO:0051289 - protein homotetramerization
GO:0044210 - 'de novo' CTP biosynthetic process
External database links:  
DIP:
DIP-10628N
ECOCYC:
CTPSYN-MONOMER
ECOLIWIKI:
b2780
INTERPRO:
IPR017926
INTERPRO:
IPR004468
INTERPRO:
IPR027417
INTERPRO:
IPR029062
INTERPRO:
IPR033828
INTERPRO:
IPR017456
PANTHER:
PTHR11550
PDB:
5U6R
PDB:
5U3C
PDB:
5U05
PDB:
5TKV
PDB:
2AD5
PDB:
1S1M
PFAM:
PF00117
PFAM:
PF06418
PRIDE:
P0A7E5
PRODB:
PRO_000023662
PROSITE:
PS51273
PROTEINMODELPORTAL:
P0A7E5
REFSEQ:
NP_417260
SMR:
P0A7E5
UNIPROT:
P0A7E5


Operon      
Name: pyrG-eno         
Operon arrangement:
Transcription unit        Promoter
eno
 
eno
eno
eno
eno
 
 
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3055 2907117 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3056 2907189 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3057 (cluster) 2907196 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_3058 (cluster) 2907241 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_3059 2907580 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3060 2907627 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3061 2907633 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3062 2907661 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3063 2907662 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3064 (cluster) 2907665 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_3065 2907682 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3066 2907694 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3067 2907716 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3068 2907923 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3069 2907932 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3070 2907956 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3072 (cluster) 2907975 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_3073 (cluster) 2908021 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_3074 (cluster) 2908226 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_3075 2908550 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3076 2908879 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3077 2908881 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3078 2909694 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3079 2909704 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3080 2909706 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3081 2909711 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3082 (cluster) 2909716 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_3083 (cluster) 2909795 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


RegulonDB