RegulonDB RegulonDB 10.6.3: Gene Form
   

rplL gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

rpoB rplJ rplL terminator anti-terminator anti-anti-terminator TSS_4782 TSS_4782 TSS_4781 TSS_4781 TSS_4780 TSS_4780 TSS_4779 TSS_4779 TSS_4778 TSS_4778 TSS_4777 TSS_4777 TSS_4776 TSS_4776 TSS_4775 TSS_4775 TSS_4774 TSS_4774 TSS_4773 TSS_4773 TSS_4772 TSS_4772 TSS_4771 TSS_4771 TSS_4770 TSS_4770 TSS_4769 TSS_4769 TSS_4768 TSS_4768 TSS_4767 TSS_4767 TSS_4766 (cluster) TSS_4766 (cluster) TSS_4765 TSS_4765 TSS_4764 TSS_4764 rpoBp rpoBp TSS_4763 TSS_4763 TSS_4762 TSS_4762 TSS_4761 (cluster) TSS_4761 (cluster) TSS_4760 (cluster) TSS_4760 (cluster) TSS_4759 TSS_4759 TSS_4758 TSS_4758 TSS_4757 (cluster) TSS_4757 (cluster) TSS_4756 (cluster) TSS_4756 (cluster) TSS_4755 TSS_4755 TSS_4754 (cluster) TSS_4754 (cluster) TSS_4753 TSS_4753 TSS_4752 TSS_4752 TSS_4751 TSS_4751 TSS_4750 TSS_4750 TSS_4749 TSS_4749

Gene      
Name: rplL    Texpresso search in the literature
Synonym(s): ECK3977, EG10873, b3986
Genome position(nucleotides): 4180560 --> 4180925 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
46.17
External database links:  
ASAP:
ABE-0013038
CGSC:
254
ECHOBASE:
EB0866
ECOCYC:
EG10873
ECOLIHUB:
rplL
OU-MICROARRAY:
b3986
REGULONDB:
b3986
STRING:
511145.b3986
M3D: rplL
COLOMBOS: rplL
PortEco: b3986


Product      
Name: 50S ribosomal subunit protein L12
Synonym(s): 50S ribosomal subunit protein L7/L12, RplL
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,ribosome
Molecular weight: 12.295
Isoelectric point: 4.304
Motif(s):
 
Type Positions Sequence
6 -> 6 D
4 -> 49 TKDQIIEAVAAMSVMDVVELISAMEEKFGVSAAAAVAVAAGPVEAA
54 -> 121 EFDVILKAAGANKVAVIKAVRGATGLGLKEAKDLVESAPAALKEGVSKDDAEALKKALEEAGAEVEVK
74 -> 74 R
70 -> 70 I

 

Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.2 - translation
  2 - information transfer --> 2.3 - protein related --> 2.3.8 - ribosomal proteins
  6 - cell structure --> 6.6 - ribosomes
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0005840 - ribosome
GO:0015934 - large ribosomal subunit
GO:0022625 - cytosolic large ribosomal subunit
molecular_function GO:0003735 - structural constituent of ribosome
GO:0005515 - protein binding
GO:0043022 - ribosome binding
GO:0042803 - protein homodimerization activity
biological_process GO:0006412 - translation
Note(s): Note(s): ...[more].
Reference(s): [1] Dai Y., et al., 2017
External database links:  
DIP:
DIP-36009N
ECOCYC:
EG10873-MONOMER
ECOLIWIKI:
b3986
INTERPRO:
IPR036235
INTERPRO:
IPR008932
INTERPRO:
IPR013823
INTERPRO:
IPR014719
INTERPRO:
IPR000206
MINT:
MINT-1277405
PANTHER:
PTHR24089:SF404
PDB:
1CTF
PDB:
5KCS
PDB:
4V9O
PDB:
4V89
PDB:
4V85
PDB:
4V7D
PDB:
4V7B
PDB:
4V5N
PDB:
4V5M
PDB:
1RQS
PDB:
1RQT
PDB:
1RQU
PDB:
1RQV
PDB:
2BCW
PDB:
3J7Z
PDB:
4UY8
PDB:
4V4V
PDB:
4V4W
PFAM:
PF00542
PFAM:
PF16320
PRIDE:
P0A7K2
PRODB:
PRO_000023818
PRODOM:
PD001326
PROTEINMODELPORTAL:
P0A7K2
REFSEQ:
NP_418413
SMR:
P0A7K2
UNIPROT:
P0A7K2


Operon      
Name: rplKAJL-rpoBC         
Operon arrangement:
Transcription unit        Promoter
rplKAJL-rpoBC
rplJL-rpoBC
rpoBC
rplL


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4749 4180008 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4750 4180015 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4751 4180019 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4752 4180450 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4753 4180456 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4754 (cluster) 4180531 forward For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_4755 4180535 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4756 (cluster) 4180541 forward For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_4757 (cluster) 4180555 forward For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_4758 4180562 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4759 4180564 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4760 (cluster) 4180570 forward For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_4761 (cluster) 4180576 forward For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_4762 4180581 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4763 4180584 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4764 4181137 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4765 4181601 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4766 (cluster) 4181777 forward For this promoter, there
Read more >
[RS-EPT-CBR] [2]
  promoter TSS_4767 4181787 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4768 4181927 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4769 4181929 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4770 4181932 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4771 4182185 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4772 4182197 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4773 4182221 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4774 4182784 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4775 4182797 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4776 4182947 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4777 4183051 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4778 4183955 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4779 4184263 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4780 4184265 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4781 4184369 forward nd [RS-EPT-CBR] [2]
  promoter TSS_4782 4184971 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Dai Y., Shortreed MR., Scalf M., Frey BL., Cesnik AJ., Solntsev S., Schaffer LV., Smith LM., 2017, Elucidating Escherichia coli Proteoform Families Using Intact-Mass Proteomics and a Global PTM Discovery Database., J Proteome Res

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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