RegulonDB RegulonDB 10.9: Gene Form
   

sbmA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

sbmA ampH yaiW sbmAp sbmAp TSS_491 TSS_491 ampHp1 ampHp1 TSS_490 TSS_490 ampHp2 ampHp2

Gene      
Name: sbmA    Texpresso search in the literature
Synonym(s): ECK0372, EG10928, b0377
Genome position(nucleotides): 396639 --> 397859 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.35
External database links:  
ASAP:
ABE-0001297
CGSC:
17914
ECHOBASE:
EB0921
ECOLIHUB:
sbmA
OU-MICROARRAY:
b0377
STRING:
511145.b0377
COLOMBOS: sbmA


Product      
Name: peptide antibiotic/peptide nucleic acid transporter
Synonym(s): SbmA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 46.459
Isoelectric point: 8.697
Motif(s):
 
Type Positions Sequence
12 -> 32 FFLSAFVWALIAVIFWQAGGG
388 -> 388 S
138 -> 158 VGVFLGIALIAVVISVLNNFF
243 -> 263 LVIAAIVWSLMGTGLLAVVGI
88 -> 108 ILGTALIIFVTWFLVEVGVAV

 

Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.am - ABC superfamily, ATP binding and membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015291 - secondary active transmembrane transporter activity
GO:0016887 - ATPase activity
GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0005524 - ATP binding
GO:0042803 - protein homodimerization activity
GO:0015638 - microcin transmembrane transporter activity
GO:0019534 - toxin transmembrane transporter activity
GO:1904680 - peptide transmembrane transporter activity
biological_process GO:0046677 - response to antibiotic
GO:0015031 - protein transport
GO:0015833 - peptide transport
GO:0042884 - microcin transport
GO:0055085 - transmembrane transport
GO:0042885 - microcin B17 transport
GO:1901998 - toxin transport
External database links:  
ECOCYC:
SBMA-MONOMER
ECOLIWIKI:
b0377
INTERPRO:
IPR009248
INTERPRO:
IPR036640
PFAM:
PF05992
PRIDE:
P0AFY6
PRODB:
PRO_000023913
REFSEQ:
NP_414911
UNIPROT:
P0AFY6


Operon      
Name: sbmA-yaiW         
Operon arrangement:
Transcription unit        Promoter
sbmA-yaiW


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_490 396323 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_491 396380 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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