RegulonDB RegulonDB 10.8: Gene Form
   

sdhB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

sucA sdhA sdhB b0725 TSS_850 TSS_850 TSS_849 TSS_849 TSS_848 (cluster) TSS_848 (cluster) TSS_847 TSS_847 sucAp sucAp TSS_846 TSS_846 TSS_845 TSS_845 TSS_844 (cluster) TSS_844 (cluster) TSS_843 (cluster) TSS_843 (cluster) TSS_842 TSS_842

Gene      
Name: sdhB    Texpresso search in the literature
Synonym(s): ECK0713, EG10932, b0724, dhsB
Genome position(nucleotides): 757689 --> 758405 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.6
External database links:  
ASAP:
 ABE-0002468
CGSC:
 17905
ECHOBASE:
 EB0925
MIM:
 612359
MIM:
 171300
MIM:
 115310
MIM:
 606864
OU-MICROARRAY:
 b0724
PortEco:
 sdhB
STRING:
 511145.b0724
COLOMBOS: sdhB


Product      
Name: succinate:quinone oxidoreductase, iron-sulfur cluster binding protein
Synonym(s): DhsB, SdhB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 26.77
Isoelectric point: 6.707
Motif(s):
 
Type Positions Sequence
8 -> 97 YRYNPDVDDAPRMQDYTLEADEGRDMMLLDALIQLKEKDPSLSFRRSCREGVCGSDGLNMNGKNGLACITPISALNQPGKKIVIRPLPGL
139 -> 169 QREKLDGLYECILCACCSTSCPSFWWNPDKF
148 -> 221 ECILCACCSTSCPSFWWNPDKFIGPAGLLAAYRFLIDSRDTETDSRLDGLSDAFSVFRCHSIMNCVSVCPKGLN
5 -> 111 FSIYRYNPDVDDAPRMQDYTLEADEGRDMMLLDALIQLKEKDPSLSFRRSCREGVCGSDGLNMNGKNGLACITPISALNQPGKKIVIRPLPGLPVIRDLVVDMGQFY

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.4 - TCA cycle
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.6 - aerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.1 - electron donors
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0005515 - protein binding
GO:0009055 - electron transfer activity
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0051536 - iron-sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0051537 - 2 iron, 2 sulfur cluster binding
GO:0008177 - succinate dehydrogenase (ubiquinone) activity
GO:0051538 - 3 iron, 4 sulfur cluster binding
biological_process GO:0006099 - tricarboxylic acid cycle
GO:0009060 - aerobic respiration
GO:0022904 - respiratory electron transport chain
GO:0055114 - oxidation-reduction process
Note(s): Note(s): ...[more].
Reference(s): [1] Condon C., et al., 1985
[2] Darlison MG., et al., 1984
External database links:  
DIP:
 DIP-10836N
ECOCYC:
 SDH-FE-S
ECOLIWIKI:
 b0724
INTERPRO:
 IPR004489
INTERPRO:
 IPR001041
INTERPRO:
 IPR025192
INTERPRO:
 IPR036010
INTERPRO:
 IPR009051
INTERPRO:
 IPR012675
INTERPRO:
 IPR017896
INTERPRO:
 IPR017900
MODBASE:
 P07014
PDB:
 2WU2
PDB:
 2WS3
PDB:
 2WP9
PDB:
 2WDV
PDB:
 2WDR
PDB:
 2WDQ
PDB:
 2AD0
PDB:
 2ACZ
PDB:
 1NEN
PDB:
 1NEK
PDB:
 2WU5
PFAM:
 PF13085
PRIDE:
 P07014
PRODB:
 PRO_000023919
PROSITE:
 PS51379
PROSITE:
 PS00198
PROSITE:
 PS51085
REFSEQ:
 NP_415252
SMR:
 P07014
UNIPROT:
 P07014


Operon      
Name: sdhCDAB-sucABCD-sdhX         
Operon arrangement:
Transcription unit        Promoter
sdhCDAB-sucABCD-sdhX
sdhDAB
sucAB
sucABCD


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, Fur, ArcA
Repressed by: FNR, ArcA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_842 756352 forward nd [RS-EPT-CBR] [3]
  promoter TSS_843 (cluster) 758036 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [3]
  promoter TSS_844 (cluster) 758044 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [3]
  promoter TSS_845 758063 forward nd [RS-EPT-CBR] [3]
  promoter TSS_846 758585 forward nd [RS-EPT-CBR] [3]
  promoter TSS_847 761388 forward nd [RS-EPT-CBR] [3]
  promoter TSS_848 (cluster) 761444 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [3]
  promoter TSS_849 761455 forward nd [RS-EPT-CBR] [3]
  promoter TSS_850 761476 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Condon C., Cammack R., Patil DS., Owen P., 1985, The succinate dehydrogenase of Escherichia coli. Immunochemical resolution and biophysical characterization of a 4-subunit enzyme complex., J Biol Chem 260(16):9427-34

 [2] Darlison MG., Guest JR., 1984, Nucleotide sequence encoding the iron-sulphur protein subunit of the succinate dehydrogenase of Escherichia coli., Biochem J 223(2):507-17

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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