RegulonDB RegulonDB 10.8: Gene Form
   

srlR gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

norR gutQ srlR gutM NsrR TSS_3019 TSS_3019 TSS_3018 (cluster) TSS_3018 (cluster) TSS_3017 (cluster) TSS_3017 (cluster) srlRp srlRp

Gene      
Name: srlR    Texpresso search in the literature
Synonym(s): ECK2702, EG10974, b2707, gutR
Genome position(nucleotides): 2829047 --> 2829820 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 48.84
External database links:  
ASAP:
 ABE-0008900
CGSC:
 152
ECHOBASE:
 EB0967
OU-MICROARRAY:
 b2707
PortEco:
 srlR
STRING:
 511145.b2707
COLOMBOS: srlR


Product      
Name: DNA-binding transcriptional repressor SrlR
Synonym(s): GutR, SrlR
Sequence: Get amino acid sequence Fasta Format
Regulator Family: DeoR
Cellular location: cytosol
Molecular weight: 28.236
Isoelectric point: 5.016
Motif(s):
 
Type Positions Sequence
74 -> 231 NTHKKELIAEAAVSFIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENAFEHFTFDKLFMGTDGIDLNAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNVVCSLESVDKLITD
20 -> 39 CSVEELAQYFDTTGTTIRKD
3 -> 58 PRQRQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVL
6 -> 61 RQAAILEYLQKQGKCSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKE

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
  3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0005515 - protein binding
GO:0003700 - DNA-binding transcription factor activity
biological_process GO:0006355 - regulation of transcription, DNA-templated
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0045892 - negative regulation of transcription, DNA-templated
Note(s): Note(s): ...[more].
Evidence: [HIFS] Human inference of function from sequence
[IEP] Inferred from expression pattern
Reference(s): [1] Yamada M., et al., 1988
External database links:  
DIP:
 DIP-10919N
ECOCYC:
 PD00283
ECOLIWIKI:
 b2707
INTERPRO:
 IPR001034
INTERPRO:
 IPR037171
INTERPRO:
 IPR036390
INTERPRO:
 IPR036388
INTERPRO:
 IPR014036
INTERPRO:
 IPR018356
MINT:
 MINT-1226226
MODBASE:
 P15082
PFAM:
 PF00455
PFAM:
 PF08220
PRIDE:
 P15082
PRODB:
 PRO_000023987
PROSITE:
 PS00894
PROSITE:
 PS51000
REFSEQ:
 NP_417187
SMART:
 SM00420
SMR:
 P15082
UNIPROT:
 P15082


Operon      
Name: srlAEBD-gutM-srlR-gutQ         
Operon arrangement:
Transcription unit        Promoter
srlAEBD-gutM-srlR-gutQ
srlR


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, H-NS, GutM
Repressed by: SrlR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3017 (cluster) 2828961 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [2]
  promoter TSS_3018 (cluster) 2829709 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [2]
  promoter TSS_3019 2829746 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Yamada M., Saier MH., 1988, Positive and negative regulators for glucitol (gut) operon expression in Escherichia coli., J Mol Biol 203(3):569-83

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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