RegulonDB RegulonDB 8.6: Gene Form
   

tdk gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

adhE tdk ychG_2 hns ychG_1 Fis Fis H-NS Fis Fis H-NS Fis H-NS Fis Fis DsrA terminator TSS_1468 TSS_1468 TSS_1467 TSS_1467 TSS_1466 TSS_1466 TSS_1465 (cluster) TSS_1465 (cluster) TSS_1464 TSS_1464 TSS_1463 TSS_1463 TSS_1462 TSS_1462 TSS_1461 TSS_1461 TSS_1460 (cluster) TSS_1460 (cluster) TSS_1459 TSS_1459 TSS_1458 TSS_1458 TSS_1457 TSS_1457 TSS_1456 TSS_1456 TSS_1455 TSS_1455 TSS_1454 TSS_1454 TSS_1453 TSS_1453 TSS_1452 (cluster) TSS_1452 (cluster) TSS_1451 TSS_1451 TSS_1450 (cluster) TSS_1450 (cluster) TSS_1449 TSS_1449 TSS_1448 TSS_1448 TSS_1447 TSS_1447 TSS_1446 TSS_1446 TSS_1445 TSS_1445 TSS_1444 TSS_1444 TSS_1443 TSS_1443 TSS_1442 TSS_1442 TSS_1441 TSS_1441 TSS_1440 TSS_1440 TSS_1439 TSS_1439 TSS_1438 TSS_1438 TSS_1437 TSS_1437 TSS_1436 TSS_1436 TSS_1435 TSS_1435 TSS_1434 TSS_1434 TSS_1433 TSS_1433 TSS_1432 TSS_1432 TSS_1431 TSS_1431 TSS_1430 TSS_1430 TSS_1429 TSS_1429 TSS_1428 TSS_1428 tdkp1 tdkp1 tdkp8 tdkp8 hnsp hnsp TSS_1427 TSS_1427 TSS_1426 TSS_1426 TSS_1425 TSS_1425 TSS_1424 (cluster) TSS_1424 (cluster) TSS_1423 TSS_1423 TSS_1422 TSS_1422 TSS_1421 TSS_1421

Gene      
Name: tdk    Texpresso search in the literature
Synonym(s): b1238
Genome position(nucleotides): 1292750 --> 1293367 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
42.23
External database links:  
ECOCYC:
EG10994
GENBANK:
1787490
GENBANK_RefSeq:
16129199
OU-MICROARRAY:
b1238
M3D: tdk
COLOMBOS: tdk
PortEco: b1238


Product      
Name: thymidine kinase/deoxyuridine kinase
Synonym(s): Tdk
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 23.457
Isoelectric point: 6.35
Motif(s):
 
Type Positions Sequence
9 -> 16 SAMNAGKS
87 -> 90 DECQ

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.33 - nucleotide and nucleoside conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0046872 - metal ion binding
GO:0016301 - kinase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0008270 - zinc ion binding
GO:0004797 - thymidine kinase activity
biological_process GO:0008152 - metabolic process
GO:0006259 - DNA metabolic process
GO:0006260 - DNA replication
GO:0009165 - nucleotide biosynthetic process
GO:0016310 - phosphorylation
GO:0009157 - deoxyribonucleoside monophosphate biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
TDK-MONOMER
EXPASY:
EC-2.7.1.145
GENPROTEC:
b1238


Operon      
Name: tdk         
Operon arrangement:
Transcription unit        Promoter
tdk
tdk


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1421 1291958 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1422 1292029 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1423 1292043 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1424 (cluster) 1292050 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_1425 1292154 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1426 1292160 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1427 1292165 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1428 1294766 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1429 1294902 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1430 1295142 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1431 1295533 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1432 1295539 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1433 1295777 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1434 1295806 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1435 1295809 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1436 1295812 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1437 1295834 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1438 1295839 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1439 1295895 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1440 1295897 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1441 1295979 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1442 1295998 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1443 1296020 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1444 1296093 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1445 1296115 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1446 1296119 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1447 1296247 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1448 1296393 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1449 1296435 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1450 (cluster) 1296511 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_1451 1296685 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1452 (cluster) 1296689 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_1453 1296824 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1454 1296832 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1455 1296851 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1456 1296892 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1457 1296905 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1458 1296914 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1459 1296940 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1460 (cluster) 1297026 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_1461 1297029 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1462 1297035 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1463 1297063 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1464 1297096 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1465 (cluster) 1297100 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_1466 1297315 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1467 1297327 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1468 1297336 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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