RegulonDB RegulonDB 8.8: Gene Form
   

tdk gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

adhE tdk ychG_2 hns ychG_1 Fis Fis H-NS Fis Fis H-NS Fis H-NS Fis Fis DsrA terminator TSS_1467 TSS_1467 TSS_1466 TSS_1466 TSS_1465 TSS_1465 TSS_1464 (cluster) TSS_1464 (cluster) TSS_1463 TSS_1463 TSS_1462 TSS_1462 TSS_1461 TSS_1461 TSS_1460 TSS_1460 TSS_1459 (cluster) TSS_1459 (cluster) TSS_1458 TSS_1458 TSS_1457 TSS_1457 TSS_1456 TSS_1456 TSS_1455 TSS_1455 TSS_1454 TSS_1454 TSS_1453 TSS_1453 TSS_1452 TSS_1452 TSS_1451 (cluster) TSS_1451 (cluster) TSS_1450 TSS_1450 TSS_1449 (cluster) TSS_1449 (cluster) TSS_1448 TSS_1448 TSS_1447 TSS_1447 TSS_1446 TSS_1446 TSS_1445 TSS_1445 TSS_1444 TSS_1444 TSS_1443 TSS_1443 TSS_1442 TSS_1442 TSS_1441 TSS_1441 TSS_1440 TSS_1440 TSS_1439 TSS_1439 TSS_1438 TSS_1438 TSS_1437 TSS_1437 TSS_1436 TSS_1436 TSS_1435 TSS_1435 TSS_1434 TSS_1434 TSS_1433 TSS_1433 TSS_1432 TSS_1432 TSS_1431 TSS_1431 TSS_1430 TSS_1430 TSS_1429 TSS_1429 TSS_1428 TSS_1428 TSS_1427 TSS_1427 tdkp1 tdkp1 tdkp8 tdkp8 hnsp hnsp TSS_1426 TSS_1426 TSS_1425 TSS_1425 TSS_1424 TSS_1424 TSS_1423 (cluster) TSS_1423 (cluster) TSS_1422 TSS_1422 TSS_1421 TSS_1421 TSS_1420 TSS_1420

Gene      
Name: tdk    Texpresso search in the literature
Synonym(s): b1238
Genome position(nucleotides): 1292750 --> 1293367 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
42.23
External database links:  
ECOCYC:
EG10994
GENBANK:
1787490
GENBANK_RefSeq:
16129199
OU-MICROARRAY:
b1238
M3D: tdk
COLOMBOS: tdk
PortEco: b1238


Product      
Name: thymidine kinase/deoxyuridine kinase
Synonym(s): Tdk
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 23.457
Isoelectric point: 6.35
Motif(s):
 
Type Positions Sequence
9 -> 16 SAMNAGKS
87 -> 90 DECQ

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.33 - nucleotide and nucleoside conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0046872 - metal ion binding
GO:0016301 - kinase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0008270 - zinc ion binding
GO:0004797 - thymidine kinase activity
biological_process GO:0008152 - metabolic process
GO:0006259 - DNA metabolic process
GO:0016310 - phosphorylation
GO:0009157 - deoxyribonucleoside monophosphate biosynthetic process
GO:0071897 - DNA biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
TDK-MONOMER
EXPASY:
EC-2.7.1.145
GENPROTEC:
b1238


Operon      
Name: tdk         
Operon arrangement:
Transcription unit        Promoter
tdk


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1420 1291958 reverse nd nd nd
  promoter TSS_1421 1292029 reverse nd nd nd
  promoter TSS_1422 1292043 reverse nd nd nd
  promoter TSS_1423 (cluster) 1292050 reverse For this promoter, there
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nd nd
  promoter TSS_1424 1292154 reverse nd nd nd
  promoter TSS_1425 1292160 reverse nd nd nd
  promoter TSS_1426 1292165 reverse nd nd nd
  promoter tdkp8 1292716 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter tdkp1 1292739 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_1427 1294766 reverse nd nd nd
  promoter TSS_1428 1294902 reverse nd nd nd
  promoter TSS_1429 1295142 reverse nd nd nd
  promoter TSS_1430 1295533 reverse nd nd nd
  promoter TSS_1431 1295539 reverse nd nd nd
  promoter TSS_1432 1295777 reverse nd nd nd
  promoter TSS_1433 1295806 reverse nd nd nd
  promoter TSS_1434 1295809 reverse nd nd nd
  promoter TSS_1435 1295812 reverse nd nd nd
  promoter TSS_1436 1295834 reverse nd nd nd
  promoter TSS_1437 1295839 reverse nd nd nd
  promoter TSS_1438 1295895 reverse nd nd nd
  promoter TSS_1439 1295897 reverse nd nd nd
  promoter TSS_1440 1295979 reverse nd nd nd
  promoter TSS_1441 1295998 reverse nd nd nd
  promoter TSS_1442 1296020 reverse nd nd nd
  promoter TSS_1443 1296093 reverse nd nd nd
  promoter TSS_1444 1296115 reverse nd nd nd
  promoter TSS_1445 1296119 reverse nd nd nd
  promoter TSS_1446 1296247 reverse nd nd nd
  promoter TSS_1447 1296393 reverse nd nd nd
  promoter TSS_1448 1296435 reverse nd nd nd
  promoter TSS_1449 (cluster) 1296511 reverse For this promoter, there
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nd nd
  promoter TSS_1450 1296685 reverse nd nd nd
  promoter TSS_1451 (cluster) 1296689 reverse For this promoter, there
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nd nd
  promoter TSS_1452 1296824 reverse nd nd nd
  promoter TSS_1453 1296832 reverse nd nd nd
  promoter TSS_1454 1296851 reverse nd nd nd
  promoter TSS_1455 1296892 reverse nd nd nd
  promoter TSS_1456 1296905 reverse nd nd nd
  promoter TSS_1457 1296914 reverse nd nd nd
  promoter TSS_1458 1296940 reverse nd nd nd
  promoter TSS_1459 (cluster) 1297026 reverse For this promoter, there
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nd nd
  promoter TSS_1460 1297029 reverse nd nd nd
  promoter TSS_1461 1297035 reverse nd nd nd
  promoter TSS_1462 1297063 reverse nd nd nd
  promoter TSS_1463 1297096 reverse nd nd nd
  promoter TSS_1464 (cluster) 1297100 reverse For this promoter, there
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nd nd
  promoter TSS_1465 1297315 reverse nd nd nd
  promoter TSS_1466 1297327 reverse nd nd nd
  promoter TSS_1467 1297336 reverse nd nd nd


Evidence    

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol. 333(2):261-78


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