RegulonDB RegulonDB 10.9: Gene Form
   

tolC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

tolC ygiB nudF ygiA SoxS Rob MarA PhoP TSS_3339 TSS_3339 TSS_3338 TSS_3338 TSS_3337 TSS_3337 TSS_3336 TSS_3336 tolCp4 tolCp4 tolCp3 tolCp3 tolCp2 tolCp2 tolCp1 tolCp1 TSS_3334 TSS_3334 TSS_3333 TSS_3333

Gene      
Name: tolC    Texpresso search in the literature
Synonym(s): ECK3026, EG11009, b3035, colE1-i, mtcB, mukA, refI, toc, weeA
Genome position(nucleotides): 3178115 --> 3179596 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.35
External database links:  
ASAP:
ABE-0009965
CGSC:
97
ECHOBASE:
EB1002
ECOLIHUB:
tolC
OU-MICROARRAY:
b3035
STRING:
511145.b3035
COLOMBOS: tolC


Product      
Name: outer membrane channel TolC
Synonym(s): MtcB, MukA, RefI, Toc, TolC, WeeA
Sequence: Get amino acid sequence Fasta Format
Cellular location: outer membrane,periplasmic space
Molecular weight: 53.741
Isoelectric point: 5.296
Motif(s):
 
Type Positions Sequence
1 -> 22 MKKLLPILIGLSLSGFSSLSQA
128 -> 128 I
178 -> 178 N
335 -> 354 SEQLESAHRSVVQTVRSSFN
83 -> 96 NSNATSASLQLTQS

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.1 - Channel-type Transporters --> 4.1.B - Beta barrel porins (The Outer Membrane Porin (OMP) Functional Superfamily)
Gene Ontology Terms (GO)  
cellular_component GO:1990196 - MacAB-TolC complex
GO:0009279 - cell outer membrane
GO:0019867 - outer membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0016021 - integral component of membrane
GO:0045203 - integral component of cell outer membrane
GO:1990281 - efflux pump complex
molecular_function GO:0047485 - protein N-terminus binding
GO:0015125 - bile acid transmembrane transporter activity
GO:0005515 - protein binding
GO:0015288 - porin activity
GO:0005216 - ion channel activity
GO:0015562 - efflux transmembrane transporter activity
GO:0042802 - identical protein binding
GO:0042931 - enterobactin transmembrane transporter activity
biological_process GO:0042493 - response to drug
GO:0009636 - response to toxic substance
GO:0046677 - response to antibiotic
GO:0014070 - response to organic cyclic compound
GO:0034220 - ion transmembrane transport
GO:0055085 - transmembrane transport
GO:0042930 - enterobactin transport
GO:0015721 - bile acid and bile salt transport
External database links:  
DIP:
DIP-11007N
ECOCYC:
EG11009-MONOMER
ECOLIWIKI:
b3035
INTERPRO:
IPR003423
INTERPRO:
IPR010130
MINT:
P02930
MODBASE:
P02930
PDB:
1EK9
PDB:
5O66
PDB:
5V5S
PDB:
1TQQ
PDB:
2VDD
PDB:
2VDE
PDB:
2WMZ
PDB:
2XMN
PDB:
5NG5
PDB:
5NIK
PDB:
5NIL
PFAM:
PF02321
PRIDE:
P02930
PRODB:
PRO_000024080
REFSEQ:
NP_417507
SMR:
P02930
UNIPROT:
P02930


Operon      
Name: tolC-ygiBC         
Operon arrangement:
Transcription unit        Promoter
tolC-ygiBC
tolC-ygiBC
tolC-ygiBC
tolC-ygiBC


Transcriptional Regulation      
Display Regulation             
Activated by: MarA, PhoP, SoxS, Rob


Regulation by small RNA    
  Display Regulation
small RNA sdsR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3333 3177710 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3334 3178001 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3336 3178133 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3337 3178889 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3338 3179055 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3339 3179717 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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