RegulonDB RegulonDB 10.8: Gene Form
   

trpE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

trpD trpE trpC trpL Cis-reg; leader anti-anti-terminator anti-terminator terminator TSS_1700 TSS_1700 TSS_1699 TSS_1699 TSS_1698 TSS_1698 TSS_1697 TSS_1697 TSS_1696 TSS_1696 TSS_1695 TSS_1695 trpCp trpCp TSS_1694 TSS_1694 TSS_1693 TSS_1693 TSS_1692 TSS_1692 TSS_1691 TSS_1691 TSS_1690 (cluster) TSS_1690 (cluster) TSS_1689 TSS_1689

Gene      
Name: trpE    Texpresso search in the literature
Synonym(s): ECK1258, EG11028, anth, b1264, tryD, tryp-4
Genome position(nucleotides): 1321384 <-- 1322946 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.38
External database links:  
ASAP:
 ABE-0004244
CGSC:
 70
ECHOBASE:
 EB1021
OU-MICROARRAY:
 b1264
PortEco:
 trpE
STRING:
 511145.b1264
COLOMBOS: trpE


Product      
Name: anthranilate synthase subunit TrpE
Synonym(s): alpha; subunit, TrpE, TryD, anthranilate synthase component I
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 57.495
Isoelectric point: 5.181
Motif(s):
 
Type Positions Sequence
147 -> 147 G
19 -> 191 DNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIQALSGNGEALLALLDNALPAGVESEQSPNCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLSAENNCPDFCFYLAETLMVIDHQKKST
483 -> 485 GAG
328 -> 329 GT
13 -> 13 C

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.15 - tryptophan
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016829 - lyase activity
GO:0046872 - metal ion binding
GO:0004049 - anthranilate synthase activity
biological_process GO:0008152 - metabolic process
GO:0000162 - tryptophan biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0009058 - biosynthetic process
GO:0009073 - aromatic amino acid family biosynthetic process
External database links:  
ECOCYC:
 ANTHRANSYNCOMPI-MONOMER
ECOLIWIKI:
 b1264
INTERPRO:
 IPR005257
INTERPRO:
 IPR019999
INTERPRO:
 IPR015890
INTERPRO:
 IPR006805
INTERPRO:
 IPR005801
MODBASE:
 P00895
PANTHER:
 PTHR11236:SF22
PFAM:
 PF04715
PFAM:
 PF00425
PRIDE:
 P00895
PRINTS:
 PR00095
PRODB:
 PRO_000024121
REFSEQ:
 NP_415780
SMR:
 P00895
SWISSMODEL:
 P00895
UNIPROT:
 P00895


Operon      
Name: trpLEDCBA         
Operon arrangement:
Transcription unit        Promoter
trpCBA
trpL
trpLEDCBA


Transcriptional Regulation      
Display Regulation             
Repressed by: TrpR


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1689 1318430 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1690 (cluster) 1318512 reverse For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_1691 1318516 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1692 1318535 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1693 1318537 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1694 1318607 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1695 1321481 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1696 1321882 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1697 1321905 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1698 1322038 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1699 1322047 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1700 1322139 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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