RegulonDB

Gene
Name:	uxaB
Synonym(s):	ECK1514, EG11065, b1521
Genome position(nucleotides):	1609229 <-- 1610680 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	52.0
External database links:

ASAP:	ABE-0005076
CGSC:	16
ECHOBASE:	EB1058
ECOLIHUB:	uxaB
OU-MICROARRAY:	b1521
STRING:	511145.b1521
COLOMBOS:	uxaB

Product

Name:

tagaturonate reductase

Synonym(s):

UxaB

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

54.808

Isoelectric point:

4.749

Motif(s):

Type	Positions	Sequence
	18 -> 29	IIQFGEGNFLRA
	17 -> 172	RIIQFGEGNFLRAFVDWQIDLLNEHTDLNSGVVVVRPIETSFPPSLSTQDGLYTTIIRGLNEKGEAVSDARLIRSVNREISVYSEYDEFLKLAHNPEMRFVFSNTTEAGISYHAGDKFDDAPAVSYPAKLTRLLFERFSHFNGALDKGWIIIPCEL
	203 -> 458	QANSFCSTLVDRIVTGYPRDEVAKLEEELGYHDGFLDTAEHFYLFVIQGPKSLATELRLDKYPLNVLIVDDIKPYKERKVAILNGAHTALVPVAFQAGLDTVGEAMNDAEICAFVEKAIYEEIIPVLDLPRDELESFASAVTGRFRNPYIKHQLLSIALNGMTKFRTRILPQLLAGQKANGTLPARLTFALAALIAFYRGERNGETYPVQDDAHWLERYQQLWSQHRDRVIGTQELVAIVLAEKDHWEQDLTQVPG

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0016491 - oxidoreductase activity GO:0008926 - mannitol-1-phosphate 5-dehydrogenase activity GO:0009026 - tagaturonate reductase activity
	biological_process	GO:0019698 - D-galacturonate catabolic process GO:0019592 - mannitol catabolic process

Note(s):

Note(s): ...[more].

Reference(s):

[1] Bardonnet N., et al., 1988
[2] Blanco C., et al., 1986
[3] Blanco C., et al., 1983
[4] Hugouvieux-Cotte-Pattat N., et al., 1983
[5] Mata-Gilsinger M., et al., 1983

External database links:

ECOCYC:

ALTRO-OXIDOREDUCT-MONOMER

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

uxaB

Operon arrangement:

Transcription unit	Promoter
uxaB	uxaBp
uxaB

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	ExuR

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	yneEp7	1609140	reverse	nd	[ICWHO]	[6]
promoter	yneEp5	1609182	reverse	nd	[ICWHO]	[6]
promoter	uxaBp2	1610737	reverse	nd	[AIPP], [ICWHO]	[6]

Evidence
[ICWHO] Inferred computationally without human oversight
[AIPP] Automated inference of promoter position

Reference(s)
[1] Bardonnet N., Trautwetter A., Couchoux-Luthaud G., Blanco C., 1988, Plasmids with the uidA reporter gene for the detection of promoters and transcription signals., Mol Gen Genet 212(2):390-2
[2] Blanco C., Mata-Gilsinger M., 1986, A DNA sequence containing the control sites for the uxaB gene of Escherichia coli., J Gen Microbiol 132(3):697-705
[3] Blanco C., Mata-Gilsinger M., Ritzenthaler P., 1983, Construction of hybrid plasmids containing the Escherichia coli uxaB gene: analysis of its regulation and direction of transcription., J Bacteriol 153(2):747-55
[4] Hugouvieux-Cotte-Pattat N., Robert-Baudouy J., 1983, Determination of the transcription direction of the uxaB gene, in Escherichia coli K12., Mol Gen Genet 189(2):334-6
[5] Mata-Gilsinger M., Ritzenthaler P., Blanco C., 1983, Characterization of the operator sites of the exu regulon in Escherichia coli K-12 by operator-constitutive mutations and repressor titration., Genetics 105(4):829-42
[6] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78