RegulonDB RegulonDB 10.10: Gene Form
   

uxuA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

uxuB gntP uxuA OxyR UxuR ExuR OxyR CRP CRP UxuR ExuR CRP terminator terminator uxuAp uxuAp gntPp gntPp

Gene      
Name: uxuA    Texpresso search in the literature
Synonym(s): ECK4313, EG11066, b4322
Genome position(nucleotides): 4551636 --> 4552820 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.35
External database links:  
ASAP:
 ABE-0014173
CGSC:
 14
ECHOBASE:
 EB1059
ECOLIHUB:
 uxuA
OU-MICROARRAY:
 b4322
STRING:
 511145.b4322
COLOMBOS: uxuA


Product      
Name: D-mannonate dehydratase
Synonym(s): UxuA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 44.838
Isoelectric point: 5.347
Motif(s):
 
Type Positions Sequence
1 -> 388 MEQTWRWYGPNDPVSLADVRQAGATGVVTALHHIPNGEVWSVEEILKRKAIIEDAGLVWSVVESVPIHEDIKTHTGNYEQWIANYQQTLRNLAQCGIRTVCYNFMPVLDWTRTDLEYVLPDGSKALRFDQIEFAAFEMHILKRPGAEADYTEEEIAQAAERFATMSDEDKARLTRNIIAGLPGAEEGYTLDQFRKHLELYKDIDKAKLRENFAVFLKAIIPVAEEVGVRMAVHPDDPPRPILGLPRIVSTIEDMQWMVDTVNSMANGFTMCTGSYGVRADNDLVDMIKQFGPRIYFTHLRSTMREDNPKTFHEAAHLNGDVDMYEVVKAIVEEEHRRKAEGKEDLIPMRPDHGHQMLDDLKKKTNPGYSAIGRLKGLAEVRGVELAIQ
52 -> 52 I

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016829 - lyase activity
GO:0008927 - mannonate dehydratase activity
GO:0008198 - ferrous iron binding
GO:0030145 - manganese ion binding
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0006064 - glucuronate catabolic process
GO:0042840 - D-glucuronate catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Robert-Baudouy J., et al., 1981
External database links:  
DIP:
 DIP-11108N
ECOCYC:
 MANNONDEHYDRAT-MONOMER
ECOLIWIKI:
 b4322
INTERPRO:
 IPR004628
INTERPRO:
 IPR036237
MODBASE:
 P24215
PANTHER:
 PTHR30387
PDB:
 4EAC
PDB:
 4EAY
PFAM:
 PF03786
PRIDE:
 P24215
PRODB:
 PRO_000024206
REFSEQ:
 NP_418742
SMR:
 P24215
UNIPROT:
 P24215


Operon      
Name: uxuAB         
Operon arrangement:
Transcription unit        Promoter
uxuAB


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: OxyR, ExuR, UxuR


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Robert-Baudouy J., Portalier R., Stoeber F., 1981, Regulation of hexuronate system genes in Escherichia coli K-12: multiple regulation of the uxu operon by exuR and uxuR gene products., J Bacteriol 145(1):211-20

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