RegulonDB RegulonDB 10.6.3: Gene Form
   

xylE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

xylE malG psiE CRP XylR XylR TSS_4874 TSS_4874 TSS_4873 TSS_4873 TSS_4872 TSS_4872 xylEp xylEp xylEp1 xylEp1 xylEp8 xylEp8

Gene      
Name: xylE    Texpresso search in the literature
Synonym(s): ECK4023, EG11076, b4031
Genome position(nucleotides): 4240779 <-- 4242254 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
49.59
Reference(s): [1] Maiden MC., et al., 1987
External database links:  
ASAP:
ABE-0013189
CGSC:
17776
ECHOBASE:
EB1069
ECOCYC:
EG11076
ECOLIHUB:
xylE
MIM:
614847
MIM:
612126
MIM:
608885
MIM:
601042
MIM:
606777
OU-MICROARRAY:
b4031
REGULONDB:
b4031
STRING:
511145.b4031
M3D: xylE
COLOMBOS: xylE
PortEco: b4031


Product      
Name: D-xylose:H+ symporter
Synonym(s): XylE, xylose MFS transporter
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 53.608
Isoelectric point: 8.244
Motif(s):
 
Type Positions Sequence
10 -> 32 IFSITLVATLGGLLFGYDTAVIS
277 -> 299 VIVIGVMLSIFQQFVGINVVLYY
288 -> 288 Q
289 -> 289 Q
397 -> 397 E

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005215 - transporter activity
GO:0015293 - symporter activity
GO:0005351 - carbohydrate:proton symporter activity
GO:0022857 - transmembrane transporter activity
GO:0015519 - D-xylose:proton symporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0015753 - D-xylose transmembrane transport
GO:0055085 - transmembrane transport
GO:1902600 - proton transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
XYLE-MONOMER
ECOLIWIKI:
b4031
INTERPRO:
IPR020846
INTERPRO:
IPR036259
INTERPRO:
IPR005829
INTERPRO:
IPR005828
INTERPRO:
IPR003663
MODBASE:
P0AGF4
PDB:
4GBZ
PDB:
4GBY
PDB:
4JA4
PDB:
4GC0
PDB:
4JA3
PDB:
4QIQ
PFAM:
PF00083
PRIDE:
P0AGF4
PRINTS:
PR00171
PRODB:
PRO_000024241
PROSITE:
PS00216
PROSITE:
PS00217
PROSITE:
PS50850
PROTEINMODELPORTAL:
P0AGF4
REFSEQ:
NP_418455
SMR:
P0AGF4
UNIPROT:
P0AGF4


Operon      
Name: xylE         
Operon arrangement:
Transcription unit        Promoter
null


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, XylR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter xylEp8 4242260 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter xylEp1 4242270 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_4872 4242704 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4873 4242731 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4874 4242830 reverse nd [RS-EPT-CBR] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Maiden MC., Davis EO., Baldwin SA., Moore DC., Henderson PJ., 1987, Mammalian and bacterial sugar transport proteins are homologous., Nature 325(6105):641-3

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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