RegulonDB

Gene
Name:	ftsL
Synonym(s):	ECK0084, EG11086, b0083, mraR, yabD
Genome position(nucleotides):	91032 --> 91397 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.27
External database links:

ASAP:	ABE-0000306
CGSC:	30402
ECHOBASE:	EB1078
OU-MICROARRAY:	b0083
PortEco:	ftsL
STRING:	511145.b0083
COLOMBOS:	ftsL

Product

Name:

cell division protein FtsL

Synonym(s):

FtsL, MraR, YabD, essential cell division protein FtsL

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

13.627

Isoelectric point:

6.795

Motif(s):

Type	Positions	Sequence
	25 -> 119	PGVIGDDLLRFGKLPLCLFICIILTAVTVVTTAHHTRLLTAQREQLVLERDALDIEWRNLILEENALGDHSRVERIATEKLQMQHVDPSQENIVV
	35 -> 57	FGKLPLCLFICIILTAVTVVTTA
	70 -> 70	L
	58 -> 85	HHTRLLTAQREQLVLERDALDIEWRNLI
	84 -> 84	L

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.1 - cell division
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane GO:0032153 - cell division site
	molecular_function	GO:0005515 - protein binding
	biological_process	GO:0051301 - cell division GO:0007049 - cell cycle GO:0043093 - FtsZ-dependent cytokinesis

Note(s):

Note(s): ...[more].

Evidence:

[IMP] Inferred from mutant phenotype

Reference(s):

[1] Guzman LM., et al., 1992

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

MINT:

PANTHER:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC

Operon arrangement:

Transcription unit	Promoter
mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC	mraZp
mraW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC	mraWp1
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC	ftsLp1
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC	ftsLp2
ftsQ	ftsQp2
ftsQAZ	ftsQp1
ftsAZ	ftsAp1
ftsZ	ftsZp4
ftsZ	ftsZp3
ftsZ	ftsZp2
lpxC	lpxCp1
lpxC	lpxCp2

Transcriptional Regulation
	Display Regulation
Repressed by:	MraZ, LexA, PdhR

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_157 (cluster)	90327	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 90327 to 90328, where the highest frequency is at position 90328. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
promoter	TSS_158	90367	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_159	92485	forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Guzman LM., Barondess JJ., Beckwith J., 1992, FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli., J Bacteriol 174(23):7716-28
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Guzman LM., Barondess JJ., Beckwith J., 1992, FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli., J Bacteriol 174(23):7716-28

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.