RegulonDB RegulonDB 10.10: Gene Form
   

ftsL gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ftsI rsmH mraZ ftsL ftsI-int murE LexA TSS_159 TSS_159 ftsLp2 ftsLp2 ftsLp1 ftsLp1 TSS_158 TSS_158 TSS_157 (cluster) TSS_157 (cluster) mraWp1 mraWp1

Gene      
Name: ftsL    Texpresso search in the literature
Synonym(s): ECK0084, EG11086, b0083, mraR, yabD
Genome position(nucleotides): 91032 --> 91397 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.27
External database links:  
ASAP:
 ABE-0000306
CGSC:
 30402
ECHOBASE:
 EB1078
ECOLIHUB:
 ftsL
OU-MICROARRAY:
 b0083
STRING:
 511145.b0083
COLOMBOS: ftsL


Product      
Name: cell division protein FtsL
Synonym(s): FtsL, MraR, YabD, essential cell division protein FtsL
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 13.627
Isoelectric point: 6.795
Motif(s):
 
Type Positions Sequence
25 -> 119 PGVIGDDLLRFGKLPLCLFICIILTAVTVVTTAHHTRLLTAQREQLVLERDALDIEWRNLILEENALGDHSRVERIATEKLQMQHVDPSQENIVV
35 -> 57 FGKLPLCLFICIILTAVTVVTTA
70 -> 70 L
58 -> 85 HHTRLLTAQREQLVLERDALDIEWRNLI
84 -> 84 L

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.1 - cell division
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0032153 - cell division site
molecular_function GO:0005515 - protein binding
biological_process GO:0051301 - cell division
GO:0007049 - cell cycle
GO:0043093 - FtsZ-dependent cytokinesis
Note(s): Note(s): ...[more].
Evidence: [IMP] Inferred from mutant phenotype
Reference(s): [1] Guzman LM., et al., 1992
[2] Svanberg Frisinger F., et al., 2021
External database links:  
DIP:
 DIP-47987N
ECOCYC:
 EG11086-MONOMER
ECOLIWIKI:
 b0083
INTERPRO:
 IPR011922
MINT:
 P0AEN4
PANTHER:
 PTHR37479
PFAM:
 PF04999
PRIDE:
 P0AEN4
PRODB:
 PRO_000022720
REFSEQ:
 NP_414625
UNIPROT:
 P0AEN4


Operon      
Name: mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC         
Operon arrangement:
Transcription unit        Promoter
mraZW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
mraW-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
ftsQ
ftsQAZ
ftsQAZ
ftsAZ
ftsZ
ftsZ
ftsZ
lpxC
lpxC


Transcriptional Regulation      
Display Regulation             
Repressed by: MraZ, LexA, PdhR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_157 (cluster) 90327 forward nd [RS-EPT-CBR] [3]
  promoter TSS_158 90367 forward nd [RS-EPT-CBR] [3]
  promoter TSS_159 92485 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Guzman LM., Barondess JJ., Beckwith J., 1992, FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli., J Bacteriol 174(23):7716-28

 [2] Svanberg Frisinger F., Jana B., Donadio S., Guardabassi L., 2021, In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in Escherichia coli., Antibiotics (Basel) 10(6)

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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