RegulonDB RegulonDB 10.8: Gene Form
   

entH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cstA entA entH CRP ybdDp2 ybdDp2 TSS_727 TSS_727 cstAp3 cstAp3 TSS_726 TSS_726 cstAp2 cstAp2 TSS_725 TSS_725 TSS_724 TSS_724 cstAp1 cstAp1 entHp entHp

Gene      
Name: entH    Texpresso search in the literature
Synonym(s): ECK0590, EG11105, b0597, ybdB
Genome position(nucleotides): 629300 --> 629713 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.76
External database links:  
ASAP:
 ABE-0002057
ECHOBASE:
 EB1097
OU-MICROARRAY:
 b0597
PortEco:
 entH
STRING:
 511145.b0597
COLOMBOS: entH


Product      
Name: proofreading thioesterase in enterobactin biosynthesis
Synonym(s): EntH, YbdB
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 14.97
Isoelectric point: 6.62
Motif(s):
 
Type Positions Sequence
54 -> 54 H
67 -> 67 S
68 -> 68 M
89 -> 92 HHRP
63 -> 63 E

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.14 - enterochelin (enterobactin)
  5 - cell processes --> 5.5 - adaptations --> 5.5.7 - Fe aquisition
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016788 - hydrolase activity, acting on ester bonds
GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0016790 - thiolester hydrolase activity
GO:0016289 - CoA hydrolase activity
GO:0042802 - identical protein binding
GO:0061522 - 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity
biological_process GO:0009239 - enterobactin biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
DIP:
 DIP-11343N
ECOCYC:
 EG11105-MONOMER
ECOLIWIKI:
 b0597
INTERPRO:
 IPR003736
INTERPRO:
 IPR026576
INTERPRO:
 IPR006683
INTERPRO:
 IPR029069
MODBASE:
 P0A8Y8
PDB:
 4K4C
PDB:
 1VH9
PDB:
 4K4D
PFAM:
 PF03061
PRIDE:
 P0A8Y8
REFSEQ:
 NP_415129
SMR:
 P0A8Y8
SWISSMODEL:
 P0A8Y8
UNIPROT:
 P0A8Y8


Operon      
Name: entCEBAH         
Operon arrangement:
Transcription unit        Promoter
entCEBA-ybdB
entH


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: Fur


Regulation by small RNA    
  Display Regulation
small RNA ryhB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_724 629856 forward nd [RS-EPT-CBR] [1]
  promoter TSS_725 629858 forward nd [RS-EPT-CBR] [1]
  promoter TSS_726 629865 forward nd [RS-EPT-CBR] [1]
  promoter TSS_727 629905 forward nd [RS-EPT-CBR] [1]
  promoter ybdDp2 631991 forward Similarity to the consensus
Read more > 		[ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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