RegulonDB

Gene
Name:	fau
Synonym(s):	ECK2907, EG11158, b2912, ygfA
Genome position(nucleotides):	3056241 --> 3056789 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.91
External database links:

ASAP:	ABE-0009559
ECHOBASE:	EB1147
ECOLIHUB:	ygfA
OU-MICROARRAY:	b2912
STRING:	511145.b2912
COLOMBOS:	fau

Product

Name:

putative 5-formyltetrahydrofolate cyclo-ligase

Synonym(s):

Fau, YgfA

Sequence:

Get amino acid sequence Fasta Format

Molecular weight:

21.105

Isoelectric point:

6.795

Motif(s):

Type	Positions	Sequence
	2 -> 176	IRQRRRALTPEQQQEMGQQAATRMMTYPPVVMAHTVAVFLSFDGELDTQPLIEQLWRAGKRVYLPVLHPFSAGNLLFLNYHPQSELVMNRLKIHEPKLDVRDVLPLSRLDVLITPLVAFDEYGQRLGMGGGFYDRTLQNWQHYKTQPVGYAHDCQLVEKLPVEEWDIPLPAVVTP
	128 -> 135	GMGGGFYD

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
Gene Ontology Terms (GO)
	molecular_function	GO:0005515 - protein binding GO:0016874 - ligase activity GO:0000166 - nucleotide binding GO:0005524 - ATP binding GO:0030272 - 5-formyltetrahydrofolate cyclo-ligase activity
	biological_process	GO:0009396 - folic acid-containing compound biosynthetic process GO:0022611 - dormancy process GO:0035999 - tetrahydrofolate interconversion

Note(s):

Note(s): ...[more].

Reference(s):

[1] Pribat A., et al., 2011

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

ssrS-fau

Operon arrangement:

Transcription unit	Promoter
ssrS	ssrSp
ssrS-ygfA	ssrSp
ssrS	ssrSp2
ssrS-ygfA	ssrSp2
ssrS	ssrSp1
ssrS-ygfA	ssrSp1

Transcriptional Regulation
	Display Regulation
Activated by:	Fis
Repressed by:	H-NS, Lrp, StpA, Fis

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_3191 (cluster)	3055983		forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Pribat A., Blaby IK., Lara-Nunez A., Jeanguenin L., Fouquet R., Frelin O., Gregory JF., Philmus B., Begley TP., de Crecy-Lagard V., Hanson AD., 2011, A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism., Funct Integr Genomics 11(3):467-78
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Pribat A., Blaby IK., Lara-Nunez A., Jeanguenin L., Fouquet R., Frelin O., Gregory JF., Philmus B., Begley TP., de Crecy-Lagard V., Hanson AD., 2011, A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism., Funct Integr Genomics 11(3):467-78

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.