RegulonDB

Gene
Name:	dinD
Synonym(s):	ECK3635, EG11193, b3645, pcsA, yicD
Genome position(nucleotides):	3817760 --> 3818584 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	45.82
External database links:

ASAP:	ABE-0011918
CGSC:	33582
ECHOBASE:	EB1179
ECOLIHUB:	dinD
OU-MICROARRAY:	b3645
STRING:	511145.b3645
COLOMBOS:	dinD

Product

Name:

DNA damage-inducible protein D

Synonym(s):

DinD, PcsA, YicD

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

31.078

Isoelectric point:

8.639

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		2 - information transfer --> 2.1 - DNA related --> 2.1.4 - DNA repair
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	biological_process	GO:0006974 - cellular response to DNA damage stimulus GO:0009432 - SOS response

Note(s):

Note(s): ...[more].

Evidence:

[IEP] Inferred from expression pattern
[IGI] Inferred from genetic interaction
[IMP] Inferred from mutant phenotype

Reference(s):

[1] Bagg A., et al., 1981
[2] Bernstein C., et al., 1999
[3] Kenyon CJ., et al., 1982
[4] Kenyon CJ., et al., 1980
[5] Ohmori H., et al., 1995
[6] Yasuda T., et al., 1996
[7] Zheng M., et al., 2001

External database links:

ECOCYC:

ECOLIWIKI:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

dinD

Operon arrangement:

Transcription unit	Promoter
dinD	dinDp

Transcriptional Regulation

Display Regulation

Repressed by:

LexA

Growth Conditions:

[1]	C: Escherichia coli\| protox assay E: Escherichia coli\| chenodeoxycholate; protox assay
[2]	C: Escherichia coli\| protox assay E: Escherichia coli\| protox assay; ursodeoxycholate
[3]	C: Escherichia coli\| protox assay E: Escherichia coli\| glycocholate; protox assay
[4]	C: Escherichia coli\| protox assay E: Escherichia coli\| deoxycholate; protox assay

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_4220	3817701		forward	nd	[RS-EPT-CBR]	[8]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Bagg A., Kenyon CJ., Walker GC., 1981, Inducibility of a gene product required for UV and chemical mutagenesis in Escherichia coli., Proc Natl Acad Sci U S A 78(9):5749-53
[2] Bernstein C., Bernstein H., Payne CM., Beard SE., Schneider J., 1999, Bile salt activation of stress response promoters in Escherichia coli., Curr Microbiol 39(2):68-72
[3] Kenyon CJ., Brent R., Ptashne M., Walker GC., 1982, Regulation of damage-inducible genes in Escherichia coli., J Mol Biol 160(3):445-57
[4] Kenyon CJ., Walker GC., 1980, DNA-damaging agents stimulate gene expression at specific loci in Escherichia coli., Proc Natl Acad Sci U S A 77(5):2819-23
[5] Ohmori H., Saito M., Yasuda T., Nagata T., Fujii T., Wachi M., Nagai K., 1995, The pcsA gene is identical to dinD in Escherichia coli., J Bacteriol 177(1):156-65
[6] Yasuda T., Nagata T., Ohmori H., 1996, Multicopy suppressors of the cold-sensitive phenotype of the pcsA68 (dinD68) mutation in Escherichia coli., J Bacteriol 178(13):3854-9
[7] Zheng M., Wang X., Templeton LJ., Smulski DR., LaRossa RA., Storz G., 2001, DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide., J Bacteriol 183(15):4562-70
[8] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.