RegulonDB RegulonDB 10.10: Gene Form
   

glmU gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

glmS glmU atpC NagC NagC GlmZ glmUp2 glmUp2 glmUp1 glmUp1 TSS_4291 (cluster) TSS_4291 (cluster) TSS_4290 TSS_4290 TSS_4289 TSS_4289 TSS_4288 TSS_4288 TSS_4287 TSS_4287 glmSp2 glmSp2 TSS_4286 TSS_4286 TSS_4285 TSS_4285 TSS_4284 TSS_4284 TSS_4283 TSS_4283 TSS_4282 TSS_4282 TSS_4281 TSS_4281

Gene      
Name: glmU    Texpresso search in the literature
Synonym(s): ECK3723, EG11198, b3730, yieA
Genome position(nucleotides): 3913830 <-- 3915200 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.66
External database links:  
ASAP:
 ABE-0012201
CGSC:
 29106
ECHOBASE:
 EB1184
ECOLIHUB:
 glmU
OU-MICROARRAY:
 b3730
STRING:
 511145.b3730
COLOMBOS: glmU


Product      
Name: fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase
Synonym(s): GlmU, YieA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 49.19
Isoelectric point: 6.517
Motif(s):
 
Type Positions Sequence
18 -> 18 R
103 -> 105 YGD
267 -> 300 THGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKN
296 -> 296 C
386 -> 387 NY

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.3 - lipopolysaccharide --> 1.6.3.1 - O antigen
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.4 - enterobacterial common antigen (surface glycolipid)
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.7 - murein (peptidoglycan)
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.10 - sugar nucleotide biosynthesis, conversions
  6 - cell structure --> 6.2 - murein
  6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016779 - nucleotidyltransferase activity
GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0046872 - metal ion binding
GO:0016746 - acyltransferase activity
GO:0003977 - UDP-N-acetylglucosamine diphosphorylase activity
GO:0019134 - glucosamine-1-phosphate N-acetyltransferase activity
GO:0000287 - magnesium ion binding
GO:0042802 - identical protein binding
biological_process GO:0008152 - metabolic process
GO:0000902 - cell morphogenesis
GO:0009103 - lipopolysaccharide biosynthetic process
GO:0009245 - lipid A biosynthetic process
GO:0009252 - peptidoglycan biosynthetic process
GO:0006048 - UDP-N-acetylglucosamine biosynthetic process
GO:0008360 - regulation of cell shape
GO:0071555 - cell wall organization
Note(s): Note(s): ...[more].
External database links:  
DIP:
 DIP-31844N
ECOCYC:
 NAG1P-URIDYLTRANS-MONOMER
ECOLIWIKI:
 b3730
INTERPRO:
 IPR005882
INTERPRO:
 IPR001451
INTERPRO:
 IPR038009
INTERPRO:
 IPR011004
INTERPRO:
 IPR018357
INTERPRO:
 IPR025877
INTERPRO:
 IPR029044
MODBASE:
 P0ACC7
PDB:
 4AA7
PDB:
 3TWD
PDB:
 2OI7
PDB:
 2OI6
PDB:
 2OI5
PDB:
 1HV9
PDB:
 1FXJ
PDB:
 1FWY
PFAM:
 PF00132
PFAM:
 PF12804
PFAM:
 PF14602
PRIDE:
 P0ACC7
PRODB:
 PRO_000022782
PROSITE:
 PS00101
REFSEQ:
 NP_418186
SMR:
 P0ACC7
UNIPROT:
 P0ACC7


Operon      
Name: glmUS         
Operon arrangement:
Transcription unit        Promoter
glmUS
glmUS


Transcriptional Regulation      
Display Regulation             
Activated by: NagC
Repressed by: NagC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4281 3912376 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4282 3912783 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4283 3912803 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4284 3913003 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4285 3913355 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4286 3913684 reverse nd [RS-EPT-CBR] [1]
  promoter glmSp2 3913811 reverse nd [ICWHO] [2]
  promoter TSS_4287 3913867 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4288 3913870 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4289 3914025 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4290 3915218 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4291 (cluster) 3915222 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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