RegulonDB RegulonDB 10.9: Gene Form
   

ivbL gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ilvB istR ivbL istR-1 CRP ppGpp anti-anti-terminator anti-terminator terminator anti-anti-terminator anti-terminator terminator istR-2p istR-2p istR-1p istR-1p ivbLp ivbLp TSS_4251 TSS_4251

Gene      
Name: ivbL    Texpresso search in the literature
Synonym(s): ECK3663, EG11275, b3672
Genome position(nucleotides): 3852890 <-- 3852988 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
58.59
External database links:  
ASAP:
ABE-0012002
ECHOBASE:
EB1253
ECOLIHUB:
ivbL
OU-MICROARRAY:
b3672
STRING:
511145.b3672
COLOMBOS: ivbL


Product      
Name: ilvBN operon leader peptide
Synonym(s): IvbL
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 3.206
Isoelectric point: 11.652
Motif(s):
 
Type Positions Sequence
1 -> 32 MTTSMLNAKLLPTAPSAAVVVVRVVVVVGNAP

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.18 - isoleucine/valine
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
biological_process GO:0008652 - cellular amino acid biosynthetic process
GO:0009082 - branched-chain amino acid biosynthetic process
GO:0009099 - valine biosynthetic process
Note(s): Note(s): ...[more].
Evidence: [IDA] Inferred from direct assay
Reference(s): [1] Friden P., et al., 1982
External database links:  
ECOCYC:
EG11275-MONOMER
ECOLIWIKI:
b3672
INTERPRO:
IPR012566
PFAM:
PF08049
PRIDE:
P03061
REFSEQ:
NP_418128
UNIPROT:
P03061


Operon      
Name: ivbL-ilvBN-uhpABC         
Operon arrangement:
Transcription unit        Promoter
uhpB
ivbL
ivbL-ilvBN
ivbL-ilvBN-uhpABC
uhpABC


Transcriptional Regulation      
Display Regulation             
Activated by: CRP


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4251 3853016 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Friden P., Newman T., Freundlich M., 1982, Nucleotide sequence of the ilvB promoter-regulatory region: a biosynthetic operon controlled by attenuation and cyclic AMP., Proc Natl Acad Sci U S A 79(20):6156-60

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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