RegulonDB RegulonDB 10.8: Gene Form
   

gabD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gabD gabT lhgD Nac gabDp1 gabDp1 gabDp2 gabDp2

Gene      
Name: gabD    Texpresso search in the literature
Synonym(s): ECK2655, EG11329, b2661
Genome position(nucleotides): 2791273 --> 2792721 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
58.32
Reference(s): [1] Bartsch K., et al., 1990
[2] Niegemann E., et al., 1993
External database links:  
ASAP:
ABE-0008758
CGSC:
729
ECHOBASE:
EB1305
MIM:
271980
MIM:
610045
OU-MICROARRAY:
b2661
PortEco:
gabD
STRING:
511145.b2661
COLOMBOS: gabD


Product      
Name: succinate-semialdehyde dehydrogenase (NADP+) GabD
Synonym(s): GabD, NADP+-dependent succinate-semialdehyde dehydrogenase
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 51.72
Isoelectric point: 5.258
Motif(s):
 
Type Positions Sequence
19 -> 477 WLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRALPAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAEEGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQLMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAVSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKY
233 -> 234 GS
180 -> 183 KPAS
156 -> 157 WN

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.31 - aminobutyrate catabolism
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.32 - putrescine catabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0102810 - glutarate-semialdehyde dehydrogenase (NADP+) activity
GO:0036243 - succinate-semialdehyde dehydrogenase (NADP+) activity
GO:0016491 - oxidoreductase activity
GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004777 - succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0009013 - succinate-semialdehyde dehydrogenase [NAD(P)+] activity
GO:0042802 - identical protein binding
GO:0050661 - NADP binding
biological_process GO:0006807 - nitrogen compound metabolic process
GO:0009450 - gamma-aminobutyric acid catabolic process
GO:0055114 - oxidation-reduction process
GO:0051289 - protein homotetramerization
External database links:  
DIP:
DIP-9723N
ECOCYC:
SUCCSEMIALDDEHYDROG-MONOMER
ECOLIWIKI:
b2661
INTERPRO:
IPR015590
INTERPRO:
IPR029510
INTERPRO:
IPR016163
INTERPRO:
IPR010102
INTERPRO:
IPR016160
INTERPRO:
IPR016161
INTERPRO:
IPR016162
MODBASE:
P25526
PDB:
3JZ4
PFAM:
PF00171
PRIDE:
P25526
PRODB:
PRO_000022739
PROSITE:
PS00070
PROSITE:
PS00687
REFSEQ:
NP_417147
SMR:
P25526
UNIPROT:
P25526


Operon      
Name: glaH-lhgD-gabDTP         
Operon arrangement:
Transcription unit        Promoter
csiD-ygaF-gabDTP
gabDTP
gabDTP


Transcriptional Regulation      
Display Regulation             
Activated by: Nac, CRP, H-NS, Lrp
Repressed by: GlaR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Bartsch K., von Johnn-Marteville A., Schulz A., 1990, Molecular analysis of two genes of the Escherichia coli gab cluster: nucleotide sequence of the glutamate:succinic semialdehyde transaminase gene (gabT) and characterization of the succinic semialdehyde dehydrogenase gene (gabD)., J Bacteriol 172(12):7035-42

 [2] Niegemann E., Schulz A., Bartsch K., 1993, Molecular organization of the Escherichia coli gab cluster: nucleotide sequence of the structural genes gabD and gabP and expression of the GABA permease gene., Arch Microbiol 160(6):454-60


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