RegulonDB RegulonDB 10.6.3: Gene Form
   

gabP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gabP gabT glaR csiRp5 csiRp5 TSS_2986 TSS_2986 csiRp3 csiRp3

Gene      
Name: gabP    Texpresso search in the literature
Synonym(s): ECK2657, EG11330, b2663
Genome position(nucleotides): 2794253 --> 2795653 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.32
External database links:  
ASAP:
ABE-0008763
CGSC:
728
ECHOBASE:
EB1306
ECOCYC:
EG11330
ECOLIHUB:
gabP
OU-MICROARRAY:
b2663
REGULONDB:
b2663
STRING:
511145.b2663
M3D: gabP
COLOMBOS: gabP
PortEco: b2663


Product      
Name: 4-aminobutanoate:H+ symporter
Synonym(s): GABA permease, GABA proton symporter, GabP, GabP permease
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 51.08
Isoelectric point: 9.853
Motif(s):
 
Type Positions Sequence
21 -> 41 MLSIAGVIGASLFVGSSVAIA
72 -> 72 T
335 -> 355 YVAVLLSTGAAFLTVVVNYYA
42 -> 62 EAGPAVLLAYLFAGLLVVMIM
200 -> 220 FGAVLSAMLITMFSFMGAEIV

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015291 - secondary active transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
GO:0015185 - gamma-aminobutyric acid transmembrane transporter activity
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0009450 - gamma-aminobutyric acid catabolic process
GO:0006865 - amino acid transport
GO:0015812 - gamma-aminobutyric acid transport
GO:0055085 - transmembrane transport
GO:0006995 - cellular response to nitrogen starvation
GO:0090549 - response to carbon starvation
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-9724N
ECOCYC:
GABP-MONOMER
ECOLIWIKI:
b2663
INTERPRO:
IPR011265
INTERPRO:
IPR004841
INTERPRO:
IPR002293
INTERPRO:
IPR004840
MINT:
MINT-1248489
PANTHER:
PTHR11785
PFAM:
PF00324
PRIDE:
P25527
PRODB:
PRO_000022740
PROSITE:
PS00218
PROTEINMODELPORTAL:
P25527
REFSEQ:
NP_417149
SMR:
P25527
UNIPROT:
P25527


Operon      
Name: glaH-lhgD-gabDTP         
Operon arrangement:
Transcription unit        Promoter
csiD-ygaF-gabDTP
gabDTP
gabDTP


Transcriptional Regulation      
Display Regulation             
Activated by: Nac, CRP, H-NS, Lrp
Repressed by: GlaR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter csiRp3 2795471 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_2986 2795625 forward nd [RS-EPT-CBR] [2]
  promoter csiRp5 2795643 forward Similarity to the consensus
Read more >
[ICWHO] [1]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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