RegulonDB RegulonDB 11.1: Gene Form
   

ubiA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

plsB ubiA ubiC BasR dgkAp1 dgkAp1 TSS_4879 TSS_4879 TSS_4878 TSS_4878 TSS_4877 TSS_4877 TSS_4876 TSS_4876

Gene      
Name: ubiA    Texpresso search in the literature
Synonym(s): ECK4032, EG11370, b4040, cyr
Genome position(nucleotides): 4253016 --> 4253888
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.78
External database links:  
ASAP:
 ABE-0013229
CGSC:
 50
ECHOBASE:
 EB1344
ECOLIHUB:
 ubiA
MIM:
 146500
MIM:
 607426
OU-MICROARRAY:
 b4040
STRING:
 511145.b4040
COLOMBOS: ubiA


Product      
Name: 4-hydroxybenzoate octaprenyltransferase
Synonym(s): Cyr, UbiA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 32.512
Isoelectric point: 9.238
Motif(s):
 
Type Positions Sequence Comment
23 -> 43 IGALLLLWPTLWALWVATPGV UniProt: Helical.
28 -> 271 LLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYYWSILVAGALFVYQQKLIANREREACFKAFMN
46 -> 66 LWILAVFVAGVWLMRAAGCVV UniProt: Helical.
100 -> 119 FVVLVLISFLLVLTLNTMTI UniProt: Helical.
141 -> 161 LPQVVLGAAFGWSIPMAFAAV UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.6 - aerobic respiration
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.11 - menaquinone, ubiquinone
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0047293 - 4-hydroxybenzoate nonaprenyltransferase activity
GO:0002083 - 4-hydroxybenzoate decaprenyltransferase activity
GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016740 - transferase activity
GO:0004659 - prenyltransferase activity
GO:0008412 - 4-hydroxybenzoate octaprenyltransferase activity
biological_process GO:0006744 - ubiquinone biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P0AGK1
ECOCYC:
 4OHBENZOATE-OCTAPRENYLTRANSFER-MONOMER
ECOLIWIKI:
 b4040
INTERPRO:
 IPR030470
INTERPRO:
 IPR039653
INTERPRO:
 IPR006370
INTERPRO:
 IPR000537
PANTHER:
 PTHR11048
PFAM:
 PF01040
PRIDE:
 P0AGK1
PRODB:
 PRO_000024155
PROSITE:
 PS00943
REFSEQ:
 NP_418464
SMR:
 P0AGK1
UNIPROT:
 P0AGK1


Operon      
Name: ubiCA         
Operon arrangement:
Transcription unit        Promoter
ubiCA


Transcriptional Regulation      
Display Regulation             
Repressed by: FNR, IHF, ArcA, NarL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4876 4252748 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4877 4255382 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4878 4255992 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4879 4256011 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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