RegulonDB RegulonDB 10.8: Gene Form
   

pgpC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yfhH pgpC tadA mltF NsrR yfhHp5 yfhHp5 pgpCp pgpCp TSS_2853 TSS_2853 TSS_2852 TSS_2852

Gene      
Name: pgpC    Texpresso search in the literature
Synonym(s): ECK2558, EG11371, b2560, yfhB
Genome position(nucleotides): 2697915 <-- 2698550 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.2
External database links:  
ASAP:
ABE-0008421
ECHOBASE:
EB1345
OU-MICROARRAY:
b2560
PortEco:
yfhB
STRING:
511145.b2560
COLOMBOS: pgpC


Product      
Name: phosphatidylglycerophosphatase C
Synonym(s): PGPC-ase, PgpC, YfhB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 24.439
Isoelectric point: 9.151
Motif(s):
 
Type Positions Sequence
9 -> 192 VFFDLDGTLHQQDMFGSFLRYLLRRQPLNALLVLPLLPIIAIALLIKGRAARWPMSLLLWGCTFGHSEARLQTLQADFVRWFRDNVTAFPLVQERLTTYLLSSDADIWLITGSPQPLVEAVYFDTPWLPRVNLIASQIQRGYGGWVLTMRCLGHEKVAQLERKIGTPLRLYSGYSDSNQDNPLL
34 -> 54 QPLNALLVLPLLPIIAIALLI

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.1 - phospholipid
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0008962 - phosphatidylglycerophosphatase activity
biological_process GO:0006629 - lipid metabolic process
GO:0046474 - glycerophospholipid biosynthetic process
GO:0016311 - dephosphorylation
GO:0016042 - lipid catabolic process
GO:0009395 - phospholipid catabolic process
GO:0006655 - phosphatidylglycerol biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
EG11371-MONOMER
ECOLIWIKI:
b2560
INTERPRO:
IPR023214
INTERPRO:
IPR036412
INTERPRO:
IPR006435
PFAM:
PF12710
PRIDE:
P0AD42
REFSEQ:
NP_417055
UNIPROT:
P0AD42


Operon      
Name: pgpC-tadA         
Operon arrangement:
Transcription unit        Promoter
pgpC-tadA


Transcriptional Regulation      
Display Regulation             
Repressed by: NsrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2852 2697755 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2853 2698592 reverse nd [RS-EPT-CBR] [1]
  promoter yfhHp5 2698707 forward Similarity to the consensus
Read more >
[ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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