RegulonDB RegulonDB 10.9: Gene Form
   

rhtB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pldB rhtB rhtC TSS_4482 (cluster) TSS_4482 (cluster) TSS_4481 TSS_4481 pldBp4 pldBp4 pldBp6 pldBp6

Gene      
Name: rhtB    Texpresso search in the literature
Synonym(s): ECK3818, EG11469, b3824, yigK
Genome position(nucleotides): 4008439 <-- 4009059 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.17
External database links:  
ASAP:
ABE-0012490
ECHOBASE:
EB1437
ECOLIHUB:
rhtB
OU-MICROARRAY:
b3824
STRING:
511145.b3824
COLOMBOS: rhtB


Product      
Name: L-homoserine/L-homoserine lactone/L-threonine exporter
Synonym(s): RhtB, YigK
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 22.427
Isoelectric point: 11.199
Motif(s):
 
Type Positions Sequence
117 -> 137 FVNLTNPKSIVFLAALFPQFI
14 -> 202 IILSLSPGSGAINTMTTSLNHGYRGAVASIAGLQTGLAIHIVLVGVGLGTLFSRSVIAFEVLKWAGAAYLIWLGIQQWRAAGAIDLKSLASTQSRRHLFQRAVFVNLTNPKSIVFLAALFPQFIMPQQPQLMQYIVLGVTTIVVDIIVMIGYATLAQRIALWIKGPKQMKALNKIFGSLFMLVGALLAS
182 -> 202 MKALNKIFGSLFMLVGALLAS
45 -> 65 GLQTGLAIHIVLVGVGLGTLF
5 -> 25 WWFAYLLTSIILSLSPGSGAI

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015291 - secondary active transmembrane transporter activity
GO:0015171 - amino acid transmembrane transporter activity
GO:0042970 - homoserine transmembrane transporter activity
GO:0015565 - threonine efflux transmembrane transporter activity
biological_process GO:0006865 - amino acid transport
GO:0003333 - amino acid transmembrane transport
GO:0015826 - threonine transport
GO:0042968 - homoserine transport
Note(s): Note(s): ...[more].
Reference(s): [1] Xu Y., et al., 2017
External database links:  
ECOCYC:
RHTB-MONOMER
ECOLIWIKI:
b3824
INTERPRO:
IPR004778
INTERPRO:
IPR001123
PANTHER:
PTHR30086
PFAM:
PF01810
PRIDE:
P0AG34
PRODB:
PRO_000023748
REFSEQ:
YP_026265
UNIPROT:
P0AG34


Operon      
Name: rhtB         
Operon arrangement:
Transcription unit        Promoter
rhtB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter pldBp6 4009014 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter pldBp4 4009023 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_4481 4009086 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4482 (cluster) 4010009 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Xu Y., Liu Y., Li F., Cao G., Zheng P., Sun J., Wen J., Zhang D., 2017, Identification of a new gene yecC involved in threonine export in Escherichia coli., FEMS Microbiol Lett 364(17)

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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