RegulonDB RegulonDB 11.1: Gene Form
   

caiB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

caiC caiB caiA Spot 42 TSS_81 TSS_81

Gene      
Name: caiB    Texpresso search in the literature
Synonym(s): ECK0039, EG11559, b0038, yaaN
Genome position(nucleotides): 37898 <-- 39115
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.63
External database links:  
ASAP:
 ABE-0000136
CGSC:
 36800
ECHOBASE:
 EB1520
ECOLIHUB:
 caiB
OU-MICROARRAY:
 b0038
STRING:
 511145.b0038
COLOMBOS: caiB


Product      
Name: γ-butyrobetainyl-CoA:carnitine CoA transferase
Synonym(s): CaiB, YaaN
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 45.127
Isoelectric point: 4.889
Motif(s):
 
Type Positions Sequence Comment
12 -> 378 LAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMSKGKDPYYAGCGLYKCADGYIVMELVGITQIEECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLATHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDT
187 -> 187 V UniProt: In strain: O44:K74..
302 -> 302 T UniProt: In strain: O44:K74..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.22 - carnitine metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0016782 - transferase activity, transferring sulphur-containing groups
GO:0008410 - CoA-transferase activity
GO:0008735 - carnitine dehydratase activity
biological_process GO:0009437 - carnitine metabolic process
GO:0042413 - carnitine catabolic process
External database links:  
ALPHAFOLD:
 P31572
ECOCYC:
 CARNDEHYDRA-MONOMER
ECOLIWIKI:
 b0038
INTERPRO:
 IPR023606
INTERPRO:
 IPR023452
INTERPRO:
 IPR003673
MODBASE:
 P31572
PDB:
 1XVV
PDB:
 1XVU
PDB:
 1XVT
PDB:
 1XK7
PDB:
 1XK6
PDB:
 1XA4
PDB:
 1XA3
PFAM:
 PF02515
PRIDE:
 P31572
PRODB:
 PRO_000022242
REFSEQ:
 NP_414580
SMR:
 P31572
UNIPROT:
 P31572


Operon      
Name: caiTABCDE         
Operon arrangement:
Transcription unit        Promoter
caiTABCDE
caiCDE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, FNR, ArcA, CaiF
Repressed by: H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_81 38400 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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