RegulonDB RegulonDB 11.1: Gene Form
   

fixC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yaaU fixC fixB fixX terminator kefFp2 kefFp2 yaaUp yaaUp

Gene      
Name: fixC    Texpresso search in the literature
Synonym(s): ECK0044, EG11564, b0043, yaaS
Genome position(nucleotides): 44180 --> 45466
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.93
External database links:  
ASAP:
 ABE-0000149
ECHOBASE:
 EB1525
ECOLIHUB:
 fixC
OU-MICROARRAY:
 b0043
STRING:
 511145.b0043
COLOMBOS: fixC


Product      
Name: putative oxidoreductase FixC
Synonym(s): FixC, YaaS, flavoprotein (electron transport), possibly involved in anaerobic carnitine metabolism
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 45.703
Isoelectric point: 5.83
Motif(s):
 
Type Positions Sequence Comment
1 -> 3 MSE UniProt: In Ref. 4..
7 -> 189 DAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFADSAPVERLITHEKLAFMTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTDVAVGVKELI
12 -> 28 GAGLAGSVAALVLAREG UniProt: FAD or NAD or NADP.
64 -> 64 D UniProt: In Ref. 1; CAA50799..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.22 - carnitine metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016491 - oxidoreductase activity
GO:0071949 - FAD binding
biological_process GO:0009437 - carnitine metabolic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P68644
ECOCYC:
 EG11564-MONOMER
ECOLIWIKI:
 b0043
INTERPRO:
 IPR039651
INTERPRO:
 IPR036188
INTERPRO:
 IPR002938
MODBASE:
 P68644
PANTHER:
 PTHR43624
PFAM:
 PF01494
PRIDE:
 P68644
PRODB:
 PRO_000022630
REFSEQ:
 NP_414585
SMR:
 P68644
UNIPROT:
 P68644


Operon      
Name: fixABCX         
Operon arrangement:
Transcription unit        Promoter
fixABCX


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, FNR, CaiF


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter kefFp2 47080 forward nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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