RegulonDB RegulonDB 10.7: Gene Form
   

moaE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ybhL moaE moaD moaC YjjQ TSS_952 TSS_952 TSS_951 (cluster) TSS_951 (cluster) TSS_950 TSS_950 ybhLp ybhLp

Gene      
Name: moaE    Texpresso search in the literature
Synonym(s): ECK0774, EG11598, b0785, chlA5
Genome position(nucleotides): 819295 --> 819747 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
56.73
External database links:  
ASAP:
ABE-0002678
CGSC:
31228
ECHOBASE:
EB1555
MIM:
252160
OU-MICROARRAY:
b0785
PORTECO:
moaE
REGULONDB:
b0785
STRING:
511145.b0785
M3D: moaE
COLOMBOS: moaE
PortEco: b0785


Product      
Name: molybdopterin synthase catalytic subunit
Synonym(s): MoaE, molybdopterin synthase large subunit
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 16.981
Isoelectric point: 5.054
Motif(s):
 
Type Positions Sequence
2 -> 150 AETKIVVGPQPFSVGEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVNALTLEHYPGMTEKALAEIVDEARNRWPLGRVTVIHRIGELWPGDEIVFVGVTSAHRSSAFEAGQFIMDYLKTRAPFWKREATPEGDRWVEARESDQQAAKRW
39 -> 39 R
103 -> 104 HR
140 -> 140 R
128 -> 128 E

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.4 - molybdenum
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0042803 - protein homodimerization activity
GO:0030366 - molybdopterin synthase activity
biological_process GO:0006777 - Mo-molybdopterin cofactor biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-10232N
ECOCYC:
EG11598-MONOMER
ECOLIWIKI:
b0785
INTERPRO:
IPR036563
INTERPRO:
IPR003448
MINT:
MINT-155543
MODBASE:
P30749
PANTHER:
PTHR23404:SF12
PDB:
3BII
PDB:
1NVJ
PDB:
1NVI
PDB:
1FMA
PDB:
1FM0
PFAM:
PF02391
PRIDE:
P30749
PROTEINMODELPORTAL:
P30749
REFSEQ:
NP_415306
SMR:
P30749
UNIPROT:
P30749


Operon      
Name: moaABCDE         
Operon arrangement:
Transcription unit        Promoter
moaABCDE
moaABCDE
moaBCDE


Transcriptional Regulation      
Display Regulation             
Activated by: FNR, ModE
Repressed by: CueR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_950 819869 forward nd [RS-EPT-CBR] [1]
  promoter TSS_951 (cluster) 819906 forward For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_952 819916 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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