RegulonDB

Gene
Name:	bacA
Synonym(s):	ECK3047, EG11665, b3057, uppP
Genome position(nucleotides):	3203310 <-- 3204131 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	52.43
External database links:

ASAP:	ABE-0010034
CGSC:	29739
ECHOBASE:	EB1616
ECOLIHUB:	bacA
OU-MICROARRAY:	b3057
STRING:	511145.b3057
COLOMBOS:	bacA

Product

Name:

undecaprenyl pyrophosphate phosphatase

Synonym(s):

BacA, UppP

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

29.759

Isoelectric point:

8.478

Motif(s):

Type	Positions	Sequence
	24 -> 49	PVSSTGHMIIVGHLLGFEGDTAKTFE
	175 -> 175	S
	190 -> 210	YAASEFSFLLAVPMMMGATAL
	26 -> 26	S
	222 -> 242	GDIPMFAVGFITAFVVALIAI

Type	Positions	Sequence
	24 -> 49	PVSSTGHMIIVGHLLGFEGDTAKTFE
	175 -> 175	S
	190 -> 210	YAASEFSFLLAVPMMMGATAL
	26 -> 26	S
	222 -> 242	GDIPMFAVGFITAFVVALIAI
	3 -> 23	DMHSLLIAAILGVVEGLTEFL
	157 -> 173	AFMIGCFQCLALWPGFS
	194 -> 213	EFSFLLAVPMMMGATALDLY
	10 -> 266	AAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAVVVMFWRRLFGLIGIHFGRPLQHEGESKGRLTLIHILLGMIPAVVLGLLFHDTIKSLFNPINVMYALVVGGLLLIAAECLKPKEPRAPGLDDMTYRQAFMIGCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATALDLYKSWGFLTSGDIPMFAVGFITAFVVALIAIKTFLQLIKRISFIPFAIYRFIVAA
	27 -> 27	S
	45 -> 65	AKTFEVVIQLGSILAVVVMFW
	50 -> 72	VVIQLGSILAVVVMFWRRLFGLI
	117 -> 139	FNPINVMYALVVGGLLLIAAECL
	170 -> 178	PGFSRSGAT
	252 -> 272	ISFIPFAIYRFIVAAAVYVVF
	92 -> 110	LIHILLGMIPAVVLGLLFH
	223 -> 247	DIPMFAVGFITAFVVALIAIKTFLQ
	116 -> 136	LFNPINVMYALVVGGLLLIAA
	173 -> 173	S
	178 -> 178	T
	261 -> 261	R
	6 -> 26	SLLIAAILGVVEGLTEFLPVS
	17 -> 21	EGLTE
	30 -> 30	H
	91 -> 113	TLIHILLGMIPAVVLGLLFHDTI
	158 -> 158	F
	189 -> 189	R
	250 -> 272	KRISFIPFAIYRFIVAAAVYVVF
	255 -> 273	IPFAIYRFIVAAAVYVVFF
	4 -> 23	MHSLLIAAILGVVEGLTEFL
	21 -> 21	E
	90 -> 110	LTLIHILLGMIPAVVLGLLFH
	161 -> 202	GCFQCLALWPGFSRSGATISGGMLMGVSRYAASEFSFLLAVP
	174 -> 222	RSGATISGGMLMGVSRYAASEFSFLLAVPMMMGATALDLYKSWGFLTSG

Classification:

Multifun Terms (GenProtEC)
		5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
		6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0016787 - hydrolase activity GO:0016462 - pyrophosphatase activity GO:0050380 - undecaprenyl-diphosphatase activity
	biological_process	GO:0000270 - peptidoglycan metabolic process GO:0009252 - peptidoglycan biosynthetic process GO:0016311 - dephosphorylation GO:0046677 - response to antibiotic GO:0008360 - regulation of cell shape GO:0071555 - cell wall organization

Note(s):

Note(s): ...[more].

Reference(s):

[1] Bickford JS., et al., 2013
[2] Ovchinnikov S., et al., 2015
[3] Workman SD., et al., 2018

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PANTHER:

PDB:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	CpxR

Reference(s)
[1] Bickford JS., Nick HS., 2013, Conservation of the PTEN catalytic motif in the bacterial undecaprenyl pyrophosphate phosphatase, BacA/UppP., Microbiology 159(Pt 12):2444-55
[2] Ovchinnikov S., Kinch L., Park H., Liao Y., Pei J., Kim DE., Kamisetty H., Grishin NV., Baker D., 2015, Large-scale determination of previously unsolved protein structures using evolutionary information., Elife 4:e09248
[3] Workman SD., Worrall LJ., Strynadka NCJ., 2018, Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling., Nat Commun 9(1):1159
[4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78