RegulonDB RegulonDB 10.6.3: Gene Form
   

galM gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

galK galT galM gpmA Fur Fur Spot42 galKp galKp TSS_936 TSS_936 galMp4 galMp4 TSS_935 (cluster) TSS_935 (cluster) TSS_934 (cluster) TSS_934 (cluster) TSS_933 TSS_933 TSS_932 TSS_932 TSS_931 TSS_931 gpmAp2 gpmAp2 gpmAp gpmAp TSS_928 TSS_928 TSS_927 TSS_927

Gene      
Name: galM    Texpresso search in the literature
Synonym(s): ECK0745, EG11698, b0756
Genome position(nucleotides): 787797 <-- 788837 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.62
External database links:  
ASAP:
ABE-0002566
CGSC:
35171
ECHOBASE:
EB1649
ECOCYC:
EG11698
ECOLIHUB:
galM
OU-MICROARRAY:
b0756
REGULONDB:
b0756
STRING:
511145.b0756
M3D: galM
COLOMBOS: galM
PortEco: b0756


Product      
Name: galactose-1-epimerase
Synonym(s): GalM
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 38.19
Isoelectric point: 4.596
Motif(s):
 
Type Positions Sequence
17 -> 342 LLTLRNNAGMVVTLMDWGATLLSARIPLSDGSVREALLGCASPECYQDQAAFLGASIGRYANRIANSRYTFDGETVTLSPSQGVNQLHGGPEGFDKRRWQIVNQNDRQVLFALSSDDGDQGFPGNLGATVQYRLTDDNRISITYRATVDKPCPVNMTNHVYFNLDGEQSDVRNHKLQILADEYLPVDEGGIPHDGLKSVAGTSFDFRSAKIIASEFLADDDQRKVKGYDHAFLLQAKGDGKKVAAHVWSADEKLQLKVYTTAPALQFYSGNFLGGTPSRGTEPYADWQGLALESEFLPDSPNHPEWPQPDCFLRPGEEYSSLTEYQ

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016853 - isomerase activity
GO:0004034 - aldose 1-epimerase activity
GO:0030246 - carbohydrate binding
biological_process GO:0005975 - carbohydrate metabolic process
GO:0006006 - glucose metabolic process
GO:0019318 - hexose metabolic process
GO:0006012 - galactose metabolic process
GO:0033499 - galactose catabolic process via UDP-galactose
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-35901N
ECOCYC:
ALDOSE1EPIM-MONOMER
ECOLIWIKI:
b0756
INTERPRO:
IPR013458
INTERPRO:
IPR018052
INTERPRO:
IPR015443
INTERPRO:
IPR014718
INTERPRO:
IPR011013
INTERPRO:
IPR008183
MINT:
MINT-1249454
MODBASE:
P0A9C3
PANTHER:
PTHR10091
PFAM:
PF01263
PRIDE:
P0A9C3
PROSITE:
PS00545
PROTEINMODELPORTAL:
P0A9C3
REFSEQ:
NP_415277
SMR:
P0A9C3
UNIPROT:
P0A9C3


Operon      
Name: galETKM         
Operon arrangement:
Transcription unit        Promoter
galK
galE
galET
galETK
galETKM
galE
galET
galETK
galETKM
galETKM


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, GalS, GalR
Repressed by: CRP, H-NS, GalS, HU, GalR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_927 787626 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_928 787629 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_931 787682 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_932 788845 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_933 788852 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_934 (cluster) 788855 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_935 (cluster) 788865 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter galMp4 788898 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_936 789995 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Mu¿¿iz-Rascado L, Garc¿¿a-Sotelo JS, Weiss V, Solano-Lira H, Mart¿¿nez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hern¿¿ndez S, Alquicira-Hern¿¿ndez K, L¿¿pez-Fuentes A, Porr¿¿n-Sotelo L, Huerta AM, Bonavides-Mart¿¿nez C, Balderas-Mart¿¿nez YI, Pannier L, Olvera M, Labastida A, Jim¿¿nez-Jacinto V, Vega-Alvarado L, Del Moral-Ch¿¿vez V, Hern¿¿ndez-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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